Dong M Z, Lin Z H, Liu S S, Xin Y N, Xuan S Y
Department of Infectious Diseases, Qingdao Municipal Hospital, Qingdao University, Qingdao 266011, China.
Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266011, China.
Zhonghua Gan Zang Bing Za Zhi. 2021 Nov 20;29(11):1095-1100. doi: 10.3760/cma.j.cn501113-20210106-00008.
To investigate the relationship between the angiotensinogen (AGT) rs5051 single nucleotide polymorphism (SNP) and the onset risk of coronary heart disease (CHD) in patients with non-alcoholic fatty liver disease (NAFLD) in the Han Chinese population. A total of 454 subjects were enrolled in this study. Among them, 140 cases were with NAFLD, 112 cases with NAFLD combined with CHD, and 202 healthy controls. Blood samples of all subjects were examined for biochemical indexes. Genotype at AGT rs5051 locus was detected by polymerase chain reaction. SPSS 21.0 statistical software was used for data statistical analysis. The differences in distribution of AGT rs5051 genotypes and alleles between the NAFLD and the control group were not statistically significant ( > 0.05). The differences in the distribution of AGT rs5051 genotypes and alleles between the NAFLD combined with CHD and the NAFLD group were statistically significant ((2) = 10.32, = 0.001; (2) = 11.72, < 0.001). Binary logistic regression analysis results showed that TC + CC genotype had increased the occurrence risk of CHD in NAFLD patients ( = 2.203, 95% : 1.322 ~ 3.670, = 0.02) than AGT rs5051 TT genotype carriers. After adjusting for gender, age, and body mass index, the TC + CC genotype still significantly increased the occurrence risk of CHD in NAFLD patients ( = 2.378, 95% : 1.384 ~ 4.087, = 0.02). In addition, AGT rs5051 C allele mutations had significantly increased the occurrence risk of CHD in patients with NAFLD ( = 2.018 before adjustment, 95% : 1.345 ~ 3.027, = 0.001; = 2.161, 95% : 1.406 ~ 3.322 after adjustment. < 0.001). This study is the first to report the correlation between AGT rs5051 polymorphism and the occurrence risk of CHD in patients with NAFLD in Han Chinese population. AGT rs5051 polymorphism can significantly increase the risk of CHD in patients with NAFLD.
探讨汉族非酒精性脂肪性肝病（NAFLD）患者血管紧张素原（AGT）rs5051单核苷酸多态性（SNP）与冠心病（CHD）发病风险的关系。本研究共纳入454名受试者。其中，NAFLD患者140例，NAFLD合并CHD患者112例，健康对照者202例。检测所有受试者血样的生化指标。采用聚合酶链反应检测AGT rs5051位点的基因型。使用SPSS 21.0统计软件进行数据统计分析。NAFLD组与对照组AGT rs5051基因型和等位基因分布差异无统计学意义（>0.05）。NAFLD合并CHD组与NAFLD组AGT rs5051基因型和等位基因分布差异有统计学意义（χ² = 10.32，P = 0.001；χ² = 11.72，P < 0.001）。二元logistic回归分析结果显示，与AGT rs5051 TT基因型携带者相比，TC + CC基因型增加了NAFLD患者CHD的发病风险（OR = 2.203，95%CI：1.3223.670，P = 0.02）。在调整性别、年龄和体重指数后，TC + CC基因型仍显著增加NAFLD患者CHD的发病风险（OR = 2.378，95%CI：1.3844.087，P = 0.02）。此外，AGT rs5051 C等位基因突变显著增加了NAFLD患者CHD的发病风险（调整前OR = 2.018，95%CI：1.3453.027，P = 0.001；调整后OR = 2.161，95%CI：3.322，P < 0.001）。本研究首次报道了汉族NAFLD患者AGT rs5051多态性与CHD发病风险的相关性。AGT rs5051多态性可显著增加NAFLD患者CHD的风险。
