Nishigaki Akemi, Tsubokura Hiroaki, Tsuzuki-Nakao Tomoko, Okada Hidetaka
Department of Obstetrics and Gynecology Kansai Medical University Osaka Japan.
Reprod Med Biol. 2021 Dec 2;21(1):e12428. doi: 10.1002/rmb2.12428. eCollection 2022 Jan.
Ovarian function is closely related to the degree of vascular network development surrounding the ovary. Maternal aging-related construction defects in this vascular network can cause ovarian hypoxia, which impedes oocyte nutrient supply, leading to physiological changes in the ovaries and oocytes. The anti-aging gene Sirtuin 1 (SIRT1) senses and adapts to ambient stress and is associated with hypoxic environments and mitochondrial biogenesis.
The present study is a literature review focusing on investigations involving the changes in SIRT1 and mitochondrial expression during hypoxia and the cytoprotective effects of the SIRT1 activator, resveratrol.
Hypoxia suppresses SIRT1 and mitochondrial expression. Resveratrol can reverse the hypoxia-induced decrease in mitochondrial and SIRT1 activity. Resveratrol suppresses the production of hypoxia-inducible factor-1α and vascular endothelial growth factor proteins.
Resveratrol exhibits protective activity against hypoxic stress and may prevent hypoxia- or aging-related mitochondrial dysfunction. Resveratrol treatment may be a potential option for infertility therapy.
卵巢功能与卵巢周围血管网络的发育程度密切相关。母体衰老相关的该血管网络结构缺陷可导致卵巢缺氧，这会阻碍卵母细胞的营养供应，进而导致卵巢和卵母细胞发生生理变化。抗衰老基因沉默调节蛋白1（SIRT1）可感知并适应环境应激，且与低氧环境和线粒体生物合成有关。
本研究是一篇文献综述，重点关注低氧期间SIRT1和线粒体表达的变化以及SIRT1激活剂白藜芦醇的细胞保护作用的相关研究。
低氧会抑制SIRT1和线粒体表达。白藜芦醇可逆转低氧诱导的线粒体和SIRT1活性降低。白藜芦醇可抑制缺氧诱导因子-1α和血管内皮生长因子蛋白的产生。
白藜芦醇对低氧应激具有保护活性，可能预防低氧或衰老相关的线粒体功能障碍。白藜芦醇治疗可能是不孕症治疗的一种潜在选择。
