Nestle Institute of Health Sciences, Nestle Research, EPFL Innovation Park, Building H, 1015 Lausanne, Switzerland.
TUM Graduate School, Technical University of Munich, 85748 Munich, Germany.
Nutrients. 2019 Jan 11;11(1):143. doi: 10.3390/nu11010143.
Resveratrol is one of the most widely studied polyphenols and it has been assigned a plethora of metabolic effects with potential health benefits. Given its low bioavailability and extensive metabolism, clinical studies using resveratrol have not always replicated in vitro observations. In this review, we discuss human metabolism and biotransformation of resveratrol, and reported molecular mechanisms of action, within the context of metabolic health and obesity. Resveratrol has been described as mimicking caloric restriction, leading to improved exercise performance and insulin sensitivity (increasing energy expenditure), as well as having a body fat-lowering effect by inhibiting adipogenesis, and increasing lipid mobilization in adipose tissue. These multi-organ effects place resveratrol as an anti-obesity bioactive of potential therapeutic use.
白藜芦醇是研究最广泛的多酚之一，它具有多种代谢作用，可能对健康有益。由于其生物利用度低和广泛的代谢，使用白藜芦醇的临床研究并不总是能复制体外观察到的结果。在这篇综述中，我们讨论了白藜芦醇在代谢健康和肥胖中的人体代谢和生物转化，以及报告的作用机制。白藜芦醇被描述为模拟热量限制，通过提高运动表现和胰岛素敏感性（增加能量消耗），以及通过抑制脂肪生成和增加脂肪组织中的脂质动员来降低体脂肪，从而产生多器官效应。这些多器官作用使白藜芦醇成为一种具有潜在治疗用途的抗肥胖生物活性物质。
