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男性系统性红斑狼疮：两种不同的表现形式。

Male systemic lupus erythematosus: Two distinct presentations.

作者信息

Akhil Sugandhi, Sharma K Sai Kanth, Kumar Dharmender

机构信息

Department of General Medicine, Tata Main Hospital, Jamshedpur, Jharkhand, India.

出版信息

J Family Med Prim Care. 2021 Oct;10(10):3910-3912. doi: 10.4103/jfmpc.jfmpc_37_21. Epub 2021 Nov 5.

DOI:10.4103/jfmpc.jfmpc_37_21
PMID:34934702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8653451/
Abstract

Systemic lupus erythematosus (SLE) multisystem autoimmune disease is characterised by a series of exacerbations and remissions. Tissues of multiple-organ systems are affected by autoantibodies. We report here two cases of SLE in male patients. Being rarer in males, diagnosis is often delayed and associated with poorer outcomes. An alert primary care physician can be instrumental in early diagnosis and ensuring better outcomes.

摘要

系统性红斑狼疮（SLE）是一种多系统自身免疫性疾病，其特征为一系列病情加重与缓解。多器官系统组织会受到自身抗体的影响。我们在此报告两例男性SLE患者。由于男性患者较为罕见，诊断往往会延迟，且预后较差。警惕的初级保健医生有助于早期诊断并确保更好的预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ce/8653451/3b0f2b7b7de2/JFMPC-10-3910-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ce/8653451/e66e24a74215/JFMPC-10-3910-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ce/8653451/6006eb94aa32/JFMPC-10-3910-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ce/8653451/3b0f2b7b7de2/JFMPC-10-3910-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ce/8653451/e66e24a74215/JFMPC-10-3910-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ce/8653451/6006eb94aa32/JFMPC-10-3910-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ce/8653451/3b0f2b7b7de2/JFMPC-10-3910-g003.jpg

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本文引用的文献

1
The Effects of Androgens on T Cells: Clues to Female Predominance in Autoimmune Liver Diseases?雄激素对 T 细胞的影响：女性在自身免疫性肝病中占优势的线索？
Front Immunol. 2020 Jul 29;11:1567. doi: 10.3389/fimmu.2020.01567. eCollection 2020.
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Prediction of prognosis and renal outcome in lupus nephritis.狼疮肾炎的预后和肾脏结局预测。
Lupus Sci Med. 2020 Feb 18;7(1):e000389. doi: 10.1136/lupus-2020-000389. eCollection 2020.
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Sex Differences in Systemic Lupus Erythematosus: Epidemiology, Clinical Considerations, and Disease Pathogenesis.
红斑狼疮的性别差异：流行病学、临床考虑因素和发病机制。
Mayo Clin Proc. 2020 Feb;95(2):384-394. doi: 10.1016/j.mayocp.2019.09.012.
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Lupus. 2010 Feb;19(2):119-29. doi: 10.1177/0961203309350755. Epub 2009 Nov 27.
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Incidence of cutaneous lupus erythematosus, 1965-2005: a population-based study.1965 - 2005年皮肤型红斑狼疮的发病率：一项基于人群的研究。
Arch Dermatol. 2009 Mar;145(3):249-53. doi: 10.1001/archdermatol.2009.21.
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Pathophysiology of cutaneous lupus erythematosus.皮肤型红斑狼疮的病理生理学
Clin Rev Allergy Immunol. 2007 Oct;33(1-2):85-106. doi: 10.1007/s12016-007-0031-x.
8
Cutaneous lupus erythematosus: a personal approach to management.皮肤型红斑狼疮：个人的治疗方法
Australas J Dermatol. 2006 Feb;47(1):13-27. doi: 10.1111/j.1440-0960.2006.00217.x.
9
Fatigue in systemic lupus erythematosus: contributions of disease activity, pain, depression, and perceived social support.系统性红斑狼疮中的疲劳：疾病活动、疼痛、抑郁及感知到的社会支持的影响
J Rheumatol. 2005 Sep;32(9):1699-705.
10
Evidence for aerobic insufficiency in women with systemic Lupus erythematosus.系统性红斑狼疮女性存在有氧代谢不足的证据。
Arthritis Rheum. 2003 Feb 15;49(1):16-22. doi: 10.1002/art.10926.