Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.
Chinese Society for Stem Cell Research, Shanghai, China.
Cell Prolif. 2022 Apr;55(4):e13141. doi: 10.1111/cpr.13141. Epub 2021 Dec 22.
Mesenchymal stem cells (MSCs) have attracted great interest for cell therapy and tissue regeneration due to their self-renewal capacity, multipotency and potent immunomodulatory effects on immune cells. However, heterogeneity of MSCs has become a prominent obstacle to limit their translation into practice, as cells from different tissue sources or each individual have great differences in their transcriptomic signatures, differentiation potential and biological functions. Therefore, there is an urgent need for consensus standard for the quality control and technical specifications of MSCs. 'Human Mesenchymal Stem Cells' is the latest set of guidelines on hMSC in China, jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research. This standard specifies the technical requirements, test methods, test regulations, instructions for use, labelling requirements, packaging requirements, storage requirements, transportation requirements and waste disposal requirements for hMSC, which is applicable to the quality control for hMSC. It was originally released by the China Society for Cell Biology on 9 January 2021. We hope that publication of these guidelines will facilitate institutional establishment, acceptance and execution of proper protocols, and accelerate the international standardization of hMSC for clinical development and therapeutic applications.
间充质干细胞（MSCs）由于其自我更新能力、多能性以及对免疫细胞的强大免疫调节作用，引起了细胞治疗和组织再生领域的极大兴趣。然而，MSCs 的异质性已成为限制其转化为实际应用的突出障碍，因为来自不同组织来源或每个个体的细胞在其转录组特征、分化潜能和生物学功能方面存在很大差异。因此，迫切需要对 MSCs 的质量控制和技术规范达成共识标准。《人源间充质干细胞》是中国最新的 hMSC 指南，由中国干细胞研究学会的专家共同起草和商定。本标准规定了 hMSC 的技术要求、试验方法、试验规程、使用说明、标签要求、包装要求、储存要求、运输要求和废物处理要求，适用于 hMSC 的质量控制。该标准最初由中国细胞生物学学会于 2021 年 1 月 9 日发布。我们希望这些指南的发布将有助于建立机构、接受和执行适当的方案，并加速 hMSC 的国际化标准化，以用于临床开发和治疗应用。
