无免疫抑制情况下卡氏肺孢子虫感染的血清学研究
Serological study of Pneumocystis carinii infection in the absence of immunosuppression.
作者信息
Gerrard M P, Eden O B, Jameson B, Craft A W
出版信息
Arch Dis Child. 1987 Feb;62(2):177-9. doi: 10.1136/adc.62.2.177.
Abstract
Serum samples from 145 children with no known immunosuppressive illness were examined by indirect immunofluorescence for antibody to Pneumocystis carinii. Positive antibody titres (greater than or equal to 1:8 dilution) were found in 69 children (48%). Antibody could not be detected in the remaining children. Previous studies have shown that at least 75% of children have antibodies to P. carinii by the age of 4 years. This study shows a lower percentage of children with detectable antibody. This may be related to geographical variation of antigen or possibly to the widespread use of co-trimoxazole.
摘要
对145名无已知免疫抑制疾病的儿童血清样本进行间接免疫荧光检测，以检测卡氏肺孢子虫抗体。69名儿童（48%）的抗体滴度呈阳性（大于或等于1:8稀释度）。其余儿童未检测到抗体。先前的研究表明，至少75%的儿童在4岁时就有卡氏肺孢子虫抗体。本研究显示可检测到抗体的儿童比例较低。这可能与抗原的地理变异有关，也可能与复方新诺明的广泛使用有关。
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