Burns S M, Read J A, Yap P L, Brettle R P
Regional Virus Laboratory, City Hospital, Edinburgh, Scotland.
J Infect. 1990 Jan;20(1):33-9. doi: 10.1016/s0163-4453(90)92280-x.
The relationship between Pneumocystis carinii antibody concentrations and acute Pneumocystis infection was investigated by testing sequential samples of serum from HIV antibody-positive patients with respiratory symptoms and HIV-negative immunocompromised patients by means of an indirect immunofluorescence assay for specific IgG antibodies to P. carinii. Loss of circulating antibody at the time of active Pneumocystis infection was observed in five patients with proven infection. Three others showed recovery of antibody coinciding with treatment and clinical recovery from infection. Concentrations of specific IgG antibody against P. carinii were measured in 40 blood donors and in six different batches of an intravenous immunoglobulin (IV Ig) preparation. Titres greater than 128 were found in the IV Ig batches examined. The use of IV Ig, either alone or in conjunction with other therapeutic agents, should therefore be considered in patients suffering from acute infection with P. carinii.
通过对有呼吸道症状的HIV抗体阳性患者和HIV阴性免疫功能低下患者的血清连续样本进行检测，采用间接免疫荧光法检测针对卡氏肺孢子虫的特异性IgG抗体，研究了卡氏肺孢子虫抗体浓度与急性卡氏肺孢子虫感染之间的关系。在5例经证实感染的患者中观察到，在活动性卡氏肺孢子虫感染时循环抗体消失。另外3例患者抗体恢复，与感染治疗及临床恢复同时发生。检测了40名献血者和6个不同批次静脉注射免疫球蛋白（IV Ig）制剂中针对卡氏肺孢子虫的特异性IgG抗体浓度。在所检测的IV Ig批次中发现滴度大于128。因此，对于患有急性卡氏肺孢子虫感染的患者，应考虑单独使用IV Ig或与其他治疗药物联合使用。
