Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region, Chinese Academy of Sciences, Guilin 541006, China.
Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan.
J Asian Nat Prod Res. 2022 Nov;24(11):1025-1032. doi: 10.1080/10286020.2021.2011241. Epub 2021 Dec 23.
Two new glycosides of methyl everninate, rhodomollosides A () and B (), were isolated from the aerial parts of a medicinal plant . The structures of and were elucidated on the basis of detailed spectroscopic analyses as well as HPLC analyses for thiazolidine derivatives of their sugar moieties. The sugar moiety of rhodomolloside A () was elucidated to be a rare monosaccharide, D-allose, while rhodomolloside B () was assigned as a D-glucoside of methyl everninate. Furthermore, they were evaluated for their cytotoxicity against RAW264.7 cells, and for their inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model.
从药用植物的地上部分分离得到两个新的甲基埃弗林糖苷，即罗地莫利oside A()和 B()。根据详细的光谱分析以及其糖部分的噻唑烷衍生物的 HPLC 分析，确定了和的结构。罗地莫利oside A()的糖部分被阐明为一种罕见的单糖，D-allo 糖，而罗地莫利oside B()被分配为甲基埃弗林的 D-葡萄糖苷。此外，还评估了它们对 RAW264.7 细胞的细胞毒性以及对脂多糖 (LPS) 刺激的小鼠巨噬细胞 RAW 264.7 细胞模型的抑制作用。
