Immunology and Biodiversity Laboratory, Department of Biology, Faculty of Sciences Ain Chock, Hassan II University, Casablanca, Morocco.
Laboratory of Health Sciences and Technologies, Higher Institute of Health Sciences, Hassan First University of Settat, Settat, Morocco.
ScientificWorldJournal. 2021 Dec 13;2021:7479540. doi: 10.1155/2021/7479540. eCollection 2021.
Inflammatory bowel disease (IBD) is a group of chronic disorders that includes two main disease forms, Crohn's disease, and ulcerative colitis. The understanding of the intestinal inflammation occurring in IBD has been immeasurably advanced by the development of the now numerous murine models of intestinal inflammation. The usefulness of this research tool in IBD arises from a convergence of underlying genetic susceptibility, immune system dysfunction, environmental factors, and shifts in gut microbiota. Due to the multifactorial feature of these diseases, different animal models have been used to investigate the underlying mechanisms and develop potential therapeutic strategies. The results of preclinical efficacy studies often inform the progression of therapeutic strategies. This review describes the distinct feature and limitations of each murine IBD model and discusses the previous and current lessons from the IBD models.
炎症性肠病（IBD）是一组慢性疾病，包括两种主要的疾病形式，克罗恩病和溃疡性结肠炎。通过开发现在众多的肠道炎症鼠模型，对 IBD 中发生的肠道炎症的理解已经得到了极大的提高。这种研究工具在 IBD 中的有用性源于潜在遗传易感性、免疫系统功能障碍、环境因素和肠道微生物群的变化的融合。由于这些疾病的多因素特征，已经使用不同的动物模型来研究潜在的发病机制和开发潜在的治疗策略。临床前疗效研究的结果通常会影响治疗策略的进展。这篇综述描述了每种鼠 IBD 模型的独特特征和局限性，并讨论了 IBD 模型的过去和现在的经验教训。
