肌醇1,4,5-三磷酸从鲎光感受器内的特定部位释放钙。
Inositol 1,4,5 trisphosphate releases calcium from specialized sites within Limulus photoreceptors.
作者信息
Payne R, Fein A
出版信息
J Cell Biol. 1987 Apr;104(4):933-7. doi: 10.1083/jcb.104.4.933.
Abstract
We have investigated the subcellular distribution and identity of inositol trisphosphate (InsP3)-sensitive calcium stores in living Limulus ventral photoreceptor cells, where light and InsP3 are known to raise intracellular calcium. We injected ventral photoreceptor cells with the photoprotein aequorin and viewed its luminescence with an image intensifier. InsP3 only elicited detectable aequorin luminescence when injected into the light-sensitive rhabdomeral (R)-lobe where aequorin luminescence induced by light was also confined. Calcium stores released by light and InsP3 are therefore localized to the R-lobe. Within the R-lobe, InsP3-induced aequorin luminescence was further confined around the injection site, due to rapid dilution and/or degradation of injected InsP3. Prominent cisternae of smooth endoplasmic reticulum are uniquely localized within the cell beneath the microvillar surface of the R-lobe (Calman, B., and S. Chamberlain, 1982, J. Gen. Physiol., 80:839-862). These cisternae are the probable site of InsP3 action.
摘要
我们研究了美洲鲎腹侧感光细胞中三磷酸肌醇（InsP3）敏感钙库的亚细胞分布及特性，在这种细胞中，已知光和InsP3可升高细胞内钙浓度。我们向腹侧感光细胞注射了光蛋白水母发光蛋白，并通过图像增强器观察其发光情况。只有将InsP3注射到对光敏感的视杆（R）叶时，才能引发可检测到的水母发光蛋白发光，而光诱导的水母发光蛋白发光也局限于此。因此，由光和InsP3释放的钙库定位于R叶。在R叶内，由于注射的InsP3迅速稀释和/或降解，InsP3诱导的水母发光蛋白发光进一步局限于注射部位周围。光面内质网的显著池独特地位于R叶微绒毛表面下方的细胞内（卡尔曼，B.，和S.钱伯林，1982年，《普通生理学杂志》，80:839 - 862）。这些池可能是InsP3作用的位点。
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本文引用的文献
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Extraction, purification and properties of aequorin, a bioluminescent protein from the luminous hydromedusan, Aequorea.来自发光水螅水母（海月水母属）的生物发光蛋白水母发光蛋白的提取、纯化及特性
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Myo-inositol phosphates obtained by alkaline hydrolysis of beef brain phosphoinositide.通过牛肉脑磷酸肌醇碱性水解得到的肌醇磷酸酯。
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Distinct lobes of Limulus ventral photoreceptors. II. Structure and ultrastructure.鲎腹侧光感受器的不同叶。II. 结构与超微结构。
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Distinct lobes of Limulus ventral photoreceptors. I. Functional and anatomical properties of lobes revealed by removal of glial cells.鲎腹侧光感受器的不同叶。I. 通过去除神经胶质细胞揭示的叶的功能和解剖学特性。
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Spatially nonuniform changes in intracellular calcium ion concentrations.细胞内钙离子浓度的空间非均匀变化。
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Quantitative pressure injection of picoliter volumes into Limulus ventral photoreceptors.将皮升体积的液体定量压力注入鲎腹侧光感受器。
Biophys J. 1983 Dec;44(3):299-304. doi: 10.1016/S0006-3495(83)84303-3.
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Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.1,4,5-三磷酸肌醇促使胰腺腺泡细胞非线粒体胞内钙库释放钙离子。
Nature. 1983;306(5938):67-9. doi: 10.1038/306067a0.
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myo-Inositol polyphosphate may be a messenger for visual excitation in Limulus photoreceptors.肌醇多磷酸可能是鲎光感受器中视觉兴奋的信使。
Nature. 1984;311(5982):160-3. doi: 10.1038/311160a0.
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