鲎腹侧光感受器中对肌醇三磷酸（InsP3）反应的快速脱敏
Fast desensitization of the response to InsP3 in Limulus ventral photoreceptors.
作者信息
Levitan I, Hillman P, Payne R
机构信息
Department of Neurobiology, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Israel.
出版信息
Biophys J. 1993 Apr;64(4):1354-60. doi: 10.1016/S0006-3495(93)81470-X.
In Limulus ventral photoreceptor cells the time-course of the desensitization of InsP3 response was measured by an injection-pair paradigm. Pressure pulses of InsP3 were delivered into the cell with various interpulse intervals. The desensitization of the response to the second injection of each pair approached totality at 200 ms, which is the duration of the response to a single pressure pulse of InsP3. Lowering extracellular calcium did not affect the time-course of the desensitization. Lowering the temperature slowed down both the time-course of the response to InsP3 and the time-course of the desensitization to the same extent. These findings suggest that the desensitization is powerful enough and its onset fast enough to contribute to the transience of the InsP3 response. The time-course of the desensitization suggests it may influence light adaptation.
在鲎腹侧光感受器细胞中，通过注射对范式测量了肌醇三磷酸（InsP3）反应脱敏的时间进程。以不同的脉冲间隔向细胞内施加InsP3压力脉冲。对每对中的第二次注射的反应脱敏在200毫秒时接近完全脱敏，这是对单个InsP3压力脉冲反应的持续时间。降低细胞外钙浓度不影响脱敏的时间进程。降低温度在相同程度上减缓了对InsP3反应的时间进程和脱敏的时间进程。这些发现表明，脱敏作用足够强大且其起始足够快，足以导致InsP3反应的短暂性。脱敏的时间进程表明它可能影响光适应。
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