School of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 6997801, Israel.
Department of Sciences of Earth, Environment and Life, University of Genoa, Corso Europa 26, 16132 Genoa, Italy.
Mar Drugs. 2021 Nov 26;19(12):669. doi: 10.3390/md19120669.
The collagen proteins family is sought-after in the pharmaceuticals, cosmetics, and food industries for various biotechnological applications. The most abundant sources of collagen are pigs and cows, but due to religious restrictions and possible disease transmission, they became less attractive. An alternative source can be found in marine invertebrates, specifically in sponges. Alas, two problems arise: (1). Growing sponges is complicated. (2). Sponge collagen has low heat tolerance, which can impose a problem for human biotechnological usage. To fill these gaps, we studied the collagen-abundant sponge . Two culture experiments were conducted: (1). A sea-based system examined the difference in growth rates of from different habitats, growing under natural seasonal conditions; (2). A land-based controlled system, which assessed the growth-rate of at different temperatures. The results reveal that from shallow habitats are growing larger and faster than individuals from colder, deeper habitats, and that the optimal temperature for growth is 25 °C. The results demonstrate that is highly fit for culture and can produce thermally stable collagen. Further research is needed to determine the best conditions for culture for collagen extract and other exciting materials for bioprospecting.
胶原蛋白家族在制药、化妆品和食品行业中因其在各种生物技术应用中的价值而备受关注。胶原蛋白的最丰富来源是猪和牛，但由于宗教限制和可能的疾病传播，它们的吸引力降低了。另一种来源可以在海洋无脊椎动物中找到，特别是在海绵中。然而，出现了两个问题：（1）. 海绵的生长过程很复杂。（2）. 海绵胶原蛋白的耐热性低，这可能会对人类生物技术的应用造成问题。为了填补这些空白，我们研究了富含胶原蛋白的海绵。进行了两项培养实验：（1）. 一个基于海洋的系统研究了来自不同栖息地的 在自然季节条件下生长时的生长率差异；（2）. 一个基于陆地的对照系统，评估了 在不同温度下的生长率。结果表明，来自浅海栖息地的 生长得更大、更快，而来自较冷、更深的栖息地的个体生长较慢， 的最佳生长温度为 25°C。这些结果表明 非常适合培养，并且可以产生热稳定的胶原蛋白。需要进一步的研究来确定 的最佳培养条件，以提取胶原蛋白和其他用于生物勘探的令人兴奋的材料。
