Almeida Mariana, Silva Tiago, Solstad Runar Gjerp, Lillebø Ana I, Calado Ricardo, Vieira Helena
CESAM-Centre for Environmental and Marine Studies, Department of Environment and Planning, Campus Universitário de Santiago, University of Aveiro, 3810-193 Aveiro, Portugal.
3B's Research Group, I3B's-Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark-Parque de Ciência e Tecnologia, 4805-694 Guimarães, Portugal.
Mar Drugs. 2024 Dec 24;23(1):2. doi: 10.3390/md23010002.
This review is focused on the research, innovation and technological breakthroughs on marine invertebrate collagens and their applications. The findings reveal that research dates back to the 1970s, and after a period of reduced activity, interest in collagens from several marine invertebrate groups was renewed around 2008, likely driven by the increased commercial interest in these biomolecules of marine origin. Research and development are predominantly reported from China and Japan, highlighting significant research interest in cnidarians (jellyfish), echinoderms (sea cucumbers, sea urchins and starfish), molluscs (squid and cuttlefish) and sponges. Co-word analysis of the literature highlights applications in regenerative medicine, the properties of hydrolysates, and biology and biochemistry studies. Innovation and the technological landscape, however, focus on fewer taxonomic groups, possibly reflecting the challenge of sustainably sourcing raw materials, with a higher number of patents coming from Asia. Globally, jellyfish collagen is the most prominent marine invertebrate source, while Asia also emphasizes the use of collagens derived from molluscs and sea cucumbers. Europe, despite fewer patents, explores a broader range of taxonomic groups. Globally, key applications registered are mostly in medical, dental and toiletry areas, with peptide preparations spanning multiple animal groups. The food domain is notably relevant for molluscs and sea cucumbers. Market trends show a strong presence of cosmetic and supplement products, aligning with market reports that predict a growing demand for marine collagens in cosmetics and personalized nutrition, particularly in targeted health supplements.
本综述聚焦于海洋无脊椎动物胶原蛋白的研究、创新及技术突破及其应用。研究结果表明，相关研究可追溯至20世纪70年代，在经历一段活动减少期后，大约在2008年，对几种海洋无脊椎动物群体胶原蛋白的兴趣再度兴起，这可能是由于对这些海洋来源生物分子的商业兴趣增加所致。研究与开发主要来自中国和日本，凸显了对刺胞动物（水母）、棘皮动物（海参、海胆和海星）、软体动物（鱿鱼和乌贼）以及海绵的重大研究兴趣。文献的共词分析突出了在再生医学、水解产物特性以及生物学和生物化学研究方面的应用。然而，创新和技术领域关注的分类群体较少，这可能反映了可持续获取原材料的挑战，亚洲拥有更多的专利。在全球范围内，水母胶原蛋白是最突出的海洋无脊椎动物来源，而亚洲也强调使用源自软体动物和海参的胶原蛋白。欧洲尽管专利较少，但探索的分类群体范围更广。在全球范围内，已注册的关键应用大多在医疗、牙科和化妆品领域，肽制剂涵盖多个动物群体。食品领域对软体动物和海参尤为重要。市场趋势显示，化妆品和补充剂产品占据很大份额，这与市场报告预测的化妆品和个性化营养领域对海洋胶原蛋白的需求不断增长相符，尤其是在针对性的健康补充剂方面。
