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视网膜前膜对用于监测青光眼的光学相干断层扫描工具的影响。

Impact of Epiretinal Membrane on Optical Coherence Tomography Tools Used for Monitoring Glaucoma.

作者信息

Pastore Marco Rocco, Merli Riccardo, Dell'Aquila Carmen, Belfanti Lorenzo, Franzon Marco, Cirigliano Gabriella, De Giacinto Chiara, Giglio Rosa, Tognetto Daniele

机构信息

Eye Clinic, Department of Medical, Surgical Sciences and Health, University of Trieste, 34129 Trieste, Italy.

Department of Mathematics and Computer Science, University of Trieste, 34129 Trieste, Italy.

出版信息

Diagnostics (Basel). 2021 Nov 26;11(12):2203. doi: 10.3390/diagnostics11122203.

DOI:10.3390/diagnostics11122203
PMID:34943441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8700323/
Abstract

BACKGROUND

Retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) measurements can be influenced by many factors including the presence of concomitant retinal diseases. The aim of this study it to assess the impact of epiretinal membrane (ERM) on RNFL and GCL assessment using optical coherence tomography (OCT).

METHODS

GCL, peripapillary RNFL (pRNFL), and Bruch's Membrane Opening Minimum Rim Width (BMO-MRW) thicknesses were analysed using an SD-OCT (Spectralis OCT) in eyes with idiopathic ERM and compared with a control group.

RESULTS

161 eyes were included, 73 eyes in the control group and 88 eyes with idiopathic ERM. The pRNFL analysis revealed a statistically significant difference between the two groups in overall and temporal sector thicknesses. For GCL thickness report, the percentage of scans in which the GCL was erroneously segmented by automatic segmentation was assessed for each eye. A statistically significant difference was found in all sectors ( < 0.001), with the exception of external nasal sector. A statistically significant difference ( < 0.001) in the GCL total volume report was found in ERM group compared to the control group. For MRW at BMO analysis, there was no statistically significant difference in MRW thickness in any sector.

CONCLUSION

In eyes with ERM, the GCL and pRNFL analysis seemed affected by the morphological retinal layers' modification. MRW-BMO did not appear to be directly affected by the presence of ERM.

摘要

背景

视网膜神经纤维层（RNFL）和神经节细胞层（GCL）的测量会受到许多因素的影响，包括合并存在的视网膜疾病。本研究的目的是评估视网膜前膜（ERM）对使用光学相干断层扫描（OCT）进行的RNFL和GCL评估的影响。

方法

使用谱域光学相干断层扫描（SD-OCT，Spectralis OCT）对特发性ERM患者的眼睛分析GCL、视乳头周围RNFL（pRNFL）和布鲁赫膜开口最小边缘宽度（BMO-MRW）厚度，并与对照组进行比较。

结果

共纳入161只眼，其中对照组73只眼，特发性ERM患者88只眼。pRNFL分析显示，两组在总体厚度和颞侧扇形厚度上存在统计学显著差异。对于GCL厚度报告，评估每只眼中GCL被自动分割错误分割的扫描百分比。除鼻外侧扇形外，所有扇形均存在统计学显著差异（P<0.001）。与对照组相比，ERM组在GCL总体积报告中存在统计学显著差异（P<0.001）。对于BMO处的MRW分析，任何扇形的MRW厚度均无统计学显著差异。

结论

在患有ERM的眼中，GCL和pRNFL分析似乎受到视网膜形态层改变的影响。MRW-BMO似乎未直接受到ERM存在的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ace/8700323/a640c85f2b6b/diagnostics-11-02203-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ace/8700323/e0b9714c880c/diagnostics-11-02203-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ace/8700323/ae3e52cb4766/diagnostics-11-02203-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ace/8700323/cd4ce63535ab/diagnostics-11-02203-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ace/8700323/1bd3e06c0261/diagnostics-11-02203-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ace/8700323/4dc0bd4f170c/diagnostics-11-02203-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ace/8700323/c07add94e762/diagnostics-11-02203-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ace/8700323/a640c85f2b6b/diagnostics-11-02203-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ace/8700323/e0b9714c880c/diagnostics-11-02203-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ace/8700323/ae3e52cb4766/diagnostics-11-02203-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ace/8700323/cd4ce63535ab/diagnostics-11-02203-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ace/8700323/1bd3e06c0261/diagnostics-11-02203-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ace/8700323/4dc0bd4f170c/diagnostics-11-02203-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ace/8700323/c07add94e762/diagnostics-11-02203-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ace/8700323/a640c85f2b6b/diagnostics-11-02203-g007.jpg

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