Amini Navid, Daneshvar Ramin, Sharifipour Farideh, Romero Pablo, Henry Sharon, Caprioli Joseph, Nouri-Mahdavi Kouros
Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States.
Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4623-4631. doi: 10.1167/iovs.17-21936.
To test the hypotheses that: (1) structure-function (SF) relationships between visual fields (VF) and Bruch's membrane opening-based minimum rim width (BMO-MRW) measurements are superior to those for peripapillary retinal nerve fiber layer (pRNFL) in perimetric glaucoma; (2) BMO-MRW measurements may extend the utility of structural measurement across the range of glaucoma severity; and (3) to estimate the influence of Bruch's membrane opening (BMO) size on BMO-MRW measurements.
One hundred eight perimetric glaucoma eyes (68 patients) with good quality spectral-domain optical coherence tomography images of the optic disc and pRNFL, and reliable VF within 6 months were recruited. Relationship of global and sectoral BMO-MRW and pRNFL thickness with corresponding VF parameters and the influence of normalizing BMO-MRW (on BMO circumference, nBMO-MRW) on SF relationships were investigated. Broken-stick models were used to compare the point at which pRNFL and BMO-MRW parameters reached their measurement floor.
The median (interquartile range) of VF mean deviation was -5.9 (-12.6 to -3.6) dB. Spearman correlation coefficients between pRNFL, BMO-MRW, and nBMO-MRW measures and corresponding VF cluster average deviations ranged between 0.55 to 0.80, 0.35 to 0.66, and 0.38 to 0.65, respectively. Bruch's membrane opening-MRW parameters demonstrated weaker SF relationships compared with pRNFL globally and in temporal, temporal-superior, and nasal-inferior sectors (P < 0.03). Normalization of BMO-MRW did not significantly influence SF relationships.
Structure-function relationships were somewhat weaker with BMO-MRW parameters compared with pRNFL in eyes with perimetric glaucoma. Bruch's membrane opening-MRW normalization did not significantly change SF relationships in this group of eyes with mild departures from average BMO size.
验证以下假设：（1）在视野计性青光眼患者中，视野（VF）与基于布鲁赫膜开口的最小视盘边缘宽度（BMO-MRW）测量值之间的结构-功能（SF）关系优于视乳头周围视网膜神经纤维层（pRNFL）的结构-功能关系；（2）BMO-MRW测量值可能会扩展结构测量在青光眼严重程度范围内的应用；（3）评估布鲁赫膜开口（BMO）大小对BMO-MRW测量值的影响。
招募了108只视野计性青光眼患眼（68例患者），这些患眼具有高质量的视盘和pRNFL的光谱域光学相干断层扫描图像，且在6个月内视野可靠。研究了整体和扇形BMO-MRW以及pRNFL厚度与相应VF参数之间的关系，以及将BMO-MRW标准化（基于BMO周长，nBMO-MRW）对SF关系的影响。采用折断棒模型比较pRNFL和BMO-MRW参数达到其测量下限的点。
VF平均偏差的中位数（四分位间距）为-5.9（-12.6至-3.6）dB。pRNFL、BMO-MRW和nBMO-MRW测量值与相应VF聚类平均偏差之间的斯皮尔曼相关系数分别在0.55至0.80、0.35至0.66和0.38至0.65之间。与pRNFL相比，布鲁赫膜开口-MRW参数在整体以及颞侧、颞上和鼻下扇形区域显示出较弱的SF关系（P<0.03）。BMO-MRW的标准化对SF关系没有显著影响。
在视野计性青光眼患眼中，与pRNFL相比，BMO-MRW参数的结构-功能关系稍弱。在这组与平均BMO大小有轻微偏差的眼中，布鲁赫膜开口-MRW标准化并未显著改变SF关系。
