Nam Ki Yup, Kim Bum Jun, Lee Woo Hyuk, Han Yong Seop
Department of Ophthalmology, Chungnam National University Sejong Hospital, Sejong 30099, Korea.
Department of Ophthalmology, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
J Clin Med. 2021 May 21;10(11):2240. doi: 10.3390/jcm10112240.
The Bruch's membrane opening-minimum rim width (BMO-MRW) is a recently introduced parameter of the neuroretinal rim. We analyzed the repeatability of spectral-domain optical coherence tomography (SD-OCT) measurements of BMO-MRW in epiretinal membrane (ERM) patients with peripapillary involvement, since the surface around the optic disc is distorted in such patients. BMO-MRW and retinal nerve fiber layer (RNFL) thickness measurements were performed using SD-OCT in prospectively enrolled ERM patients and age-matched healthy control individuals. After two consecutive measurements with a 5 min interval, repeatability was analyzed using the intraclass correlation coefficient (ICC), repeatability coefficient (RC), and coefficient of variation (CV). Fifty-two eyes of 52 ERM patients and 62 eyes of 62 healthy controls were included in the study. The ICCs of the mean BMO-MRW/RNFL thickness measurements were 0.999/0.985 in ERM eyes and 0.999/0.999 in normal eyes, respectively. The RC values of mean BMO-MRW/RNFL thickness measurements were 9.0/6.25 μm in ERM eyes and 4.61/0.92 μm in normal eyes, respectively. The CV values were 0.91% and 1.45% for BMO-MRW and RNFL thickness in ERM eyes, and 0.63% and 0.33% in normal eyes, respectively. In ERM eyes, the RC, CV of average BMO-MRW were 1.9 and 1.4 times greater than those of normal eyes, but 6.8 and 4.4 times greater for average RNFL thickness. BMO-MRW and RNFL thickness showed good repeatability in the diseased eyes with peripapillary involvement and healthy control eyes. Based on the ICC, RC, and CV values, the repeatability of BMO-MRW measurements in peripapillary membrane patients was better than that of RNFL thickness.
布鲁赫膜开口最小边缘宽度（BMO-MRW）是最近引入的神经视网膜边缘参数。我们分析了黄斑前膜（ERM）累及视乳头周围患者中BMO-MRW的频域光学相干断层扫描（SD-OCT）测量的可重复性，因为此类患者视盘周围表面会发生变形。在前瞻性纳入的ERM患者和年龄匹配的健康对照个体中，使用SD-OCT进行BMO-MRW和视网膜神经纤维层（RNFL）厚度测量。在间隔5分钟进行连续两次测量后，使用组内相关系数（ICC）、可重复性系数（RC）和变异系数（CV）分析可重复性。52例ERM患者的52只眼和62例健康对照的62只眼纳入研究。ERM患眼中平均BMO-MRW/RNFL厚度测量的ICC分别为0.999/0.985，正常眼中为0.999/0.999。ERM患眼中平均BMO-MRW/RNFL厚度测量的RC值分别为9.0/6.25μm，正常眼中为4.61/0.92μm。ERM患眼中BMO-MRW和RNFL厚度的CV值分别为0.91%和1.45%，正常眼中分别为0.63%和0.33%。在ERM患眼中，平均BMO-MRW的RC、CV分别是正常眼的1.9倍和1.4倍，但平均RNFL厚度则分别是6.8倍和4.4倍。BMO-MRW和RNFL厚度在视乳头周围受累的患眼和健康对照眼中均显示出良好的可重复性。基于ICC、RC和CV值，视乳头周围膜患者中BMO-MRW测量的可重复性优于RNFL厚度。
