微量胸苷对甲氧苄啶-磺胺甲恶唑抗表皮葡萄球菌活性的影响
Effect of minimal amounts of thymidine on activity of trimethoprim-sulfamethoxazole against Staphylococcus epidermidis.
作者信息
Jones C, Stevens D L, Ojo O
出版信息
Antimicrob Agents Chemother. 1987 Feb;31(2):144-7. doi: 10.1128/AAC.31.2.144.
Abstract
The antibacterial activity of trimethoprim-sulfamethoxazole against 99 strains of Staphylococcus epidermidis was tested on media known to be low in thymidine content, as determined by screening with Streptococcus faecalis. Eighty-one percent of the isolates were susceptible by agar dilution. Trimethoprim-sulfamethoxazole was bactericidal against two strains of S. epidermidis when thymidine phosphorylase was added to the medium, indicating utilization of minimal amounts of thymidine that were undetected by screening. Because bacteria vary in their utilization of thymidine and body tissues vary in thymidine content, in vitro susceptibility tests may not correlate with in vivo bactericidal activity.
摘要
通过用粪链球菌进行筛选，在已知胸苷含量低的培养基上测试了甲氧苄啶-磺胺甲恶唑对99株表皮葡萄球菌的抗菌活性。通过琼脂稀释法，81%的分离株敏感。当向培养基中添加胸苷磷酸化酶时，甲氧苄啶-磺胺甲恶唑对两株表皮葡萄球菌具有杀菌作用，这表明利用了筛选未检测到的极少量胸苷。由于细菌对胸苷的利用情况不同，且身体组织中的胸苷含量也不同，因此体外药敏试验可能与体内杀菌活性不相关。
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