Eley John G, Haga Catherine W, Keller Asaf, Lazenby Ellis M, Raver Charles, Rusek Adam, Dilmanian Farrokh Avraham, Krishnan Sunil, Waddell Jaylyn
Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Cancers (Basel). 2021 Dec 9;13(24):6207. doi: 10.3390/cancers13246207.
The purpose of this work was to investigate whether minibeam therapy with heavy ions might offer improvements of the therapeutic ratio for the treatment of human brain cancers. To assess neurotoxicity, we irradiated normal juvenile rats using 120 MeV lithium-7 ions at an absorbed integral dose of 20 Gy. Beams were configured either as a solid parallel circular beam or as an array of planar parallel minibeams having 300-micron width and 1-mm center-to-center spacing within a circular array. We followed animals for 6 months after treatment and utilized behavioral testing and immunohistochemical studies to investigate the resulting cognitive impairment and chronic pathologic changes. We found both solid-beam therapy and minibeam therapy to result in cognitive impairment compared with sham controls, with no apparent reduction in neurotoxicity using heavy ion minibeams instead of solid beams under the conditions of this study.
这项工作的目的是研究重离子微束疗法是否能提高人类脑癌治疗的治疗比。为了评估神经毒性，我们用120兆电子伏特的锂-7离子以20戈瑞的吸收积分剂量照射正常幼鼠。束流配置为实心平行圆形束或平面平行微束阵列，微束宽度为300微米，圆形阵列内中心距为1毫米。治疗后我们对动物进行了6个月的跟踪，并利用行为测试和免疫组化研究来调查由此产生的认知障碍和慢性病理变化。我们发现，与假手术对照组相比，实心束疗法和微束疗法均导致认知障碍，在本研究条件下，使用重离子微束而非实心束并未明显降低神经毒性。
