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眼部血管变化：脉络膜厚度作为阿尔茨海默病的早期生物标志物？

Ocular Vascular Changes: Choroidal Thickness as an Early Biomarker for Alzheimer's Disease?

作者信息

Villa Chiara

机构信息

School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.

出版信息

J Pers Med. 2021 Dec 14;11(12):1365. doi: 10.3390/jpm11121365.

DOI:10.3390/jpm11121365
PMID:34945837
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8703410/
Abstract

Alzheimer's disease (AD) is an age-related neurodegenerative and progressive disorder representing the most common form of dementia among the elderly [...].

摘要

阿尔茨海默病（AD）是一种与年龄相关的神经退行性进展性疾病，是老年人中最常见的痴呆形式[……]

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Ocular Vascular Changes: Choroidal Thickness as an Early Biomarker for Alzheimer's Disease?眼部血管变化：脉络膜厚度作为阿尔茨海默病的早期生物标志物？
J Pers Med. 2021 Dec 14;11(12):1365. doi: 10.3390/jpm11121365.
2
Ocular Vascular Changes in Mild Alzheimer's Disease Patients: Foveal Avascular Zone, Choroidal Thickness, and ONH Hemoglobin Analysis.轻度阿尔茨海默病患者的眼部血管变化：中心凹无血管区、脉络膜厚度及视盘血红蛋白分析
J Pers Med. 2020 Nov 15;10(4):231. doi: 10.3390/jpm10040231.
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Relationship Between Alzheimer's Disease and Retinal Choroidal Thickness: A Cross-Sectional Study.阿尔茨海默病与脉络膜视网膜厚度的关系：一项横断面研究。
J Alzheimers Dis. 2021;80(1):407-419. doi: 10.3233/JAD-201142.
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Choroidal thinning: Alzheimer's disease and aging.脉络膜变薄：阿尔茨海默病与衰老
Alzheimers Dement (Amst). 2017 Mar 30;8:11-17. doi: 10.1016/j.dadm.2017.03.004. eCollection 2017.
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The Eye As a Biomarker for Alzheimer's Disease.眼睛作为阿尔茨海默病的生物标志物
Front Neurosci. 2016 Nov 17;10:536. doi: 10.3389/fnins.2016.00536. eCollection 2016.
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Choroidal thinning as a new finding in Alzheimer's disease: evidence from enhanced depth imaging spectral domain optical coherence tomography.脉络膜变薄作为阿尔茨海默病的一项新发现：来自增强深度成像光谱域光学相干断层扫描的证据
J Alzheimers Dis. 2014;40(4):907-17. doi: 10.3233/JAD-132039.
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Ocular changes in TgF344-AD rat model of Alzheimer's disease.阿尔茨海默病 TgF344-AD 大鼠模型的眼部变化。
Invest Ophthalmol Vis Sci. 2014 Jan 29;55(1):523-34. doi: 10.1167/iovs.13-12888.
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Unraveling the genes implicated in Alzheimer's disease.揭示与阿尔茨海默病相关的基因。
Biomed Rep. 2017 Aug;7(2):105-114. doi: 10.3892/br.2017.927. Epub 2017 Jun 14.
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What is 'early onset dementia'?什么是“早发性痴呆症”？
Psychogeriatrics. 2009 Jun;9(2):67-72. doi: 10.1111/j.1479-8301.2009.00274.x.
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Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer's Disease.在患有硬性玻璃膜疣且无阿尔茨海默病高遗传风险的受试者中，黄斑无血管区和脉络膜厚度降低。
Biomedicines. 2021 Jun 2;9(6):638. doi: 10.3390/biomedicines9060638.

引用本文的文献

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Association between choroidal microvasculature in the eye and Alzheimer's disease risk in cognitively healthy mid-life adults: A pilot study.眼部脉络膜微血管与认知功能正常的中年成年人患阿尔茨海默病风险之间的关联：一项试点研究。
Alzheimers Dement (Amst). 2025 Jan 16;17(1):e70075. doi: 10.1002/dad2.70075. eCollection 2025 Jan-Mar.

本文引用的文献

1
Retinal biomarkers in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis.阿尔茨海默病和轻度认知障碍的视网膜生物标志物：系统评价和荟萃分析。
Ageing Res Rev. 2021 Aug;69:101361. doi: 10.1016/j.arr.2021.101361. Epub 2021 May 14.
2
Biomarkers for Alzheimer's Disease: Where Do We Stand and Where Are We Going?阿尔茨海默病的生物标志物：我们现状如何，又将走向何方？
J Pers Med. 2020 Nov 20;10(4):238. doi: 10.3390/jpm10040238.
3
Ocular Vascular Changes in Mild Alzheimer's Disease Patients: Foveal Avascular Zone, Choroidal Thickness, and ONH Hemoglobin Analysis.轻度阿尔茨海默病患者的眼部血管变化：中心凹无血管区、脉络膜厚度及视盘血红蛋白分析
J Pers Med. 2020 Nov 15;10(4):231. doi: 10.3390/jpm10040231.
4
Economic burden of Alzheimer disease and managed care considerations.阿尔茨海默病的经济负担和管理式医疗考虑因素。
Am J Manag Care. 2020 Aug;26(8 Suppl):S177-S183. doi: 10.37765/ajmc.2020.88482.
5
Ocular biomarkers for cognitive impairment in nonagenarians; a prospective cross-sectional study.九旬老人认知障碍的眼生物标志物：一项前瞻性横断面研究。
BMC Geriatr. 2020 Apr 28;20(1):155. doi: 10.1186/s12877-020-01556-1.
6
The neuropathological diagnosis of Alzheimer's disease.阿尔茨海默病的神经病理学诊断。
Mol Neurodegener. 2019 Aug 2;14(1):32. doi: 10.1186/s13024-019-0333-5.
7
Identification of Retinal Biomarkers in Alzheimer's Disease Using Optical Coherence Tomography: Recent Insights, Challenges, and Opportunities.利用光学相干断层扫描技术识别阿尔茨海默病中的视网膜生物标志物：最新见解、挑战与机遇
J Clin Med. 2019 Jul 9;8(7):996. doi: 10.3390/jcm8070996.
8
The past, present, and future of disease-modifying therapies for Alzheimer's disease.阿尔茨海默病的疾病修饰治疗的过去、现在和未来。
Proc Jpn Acad Ser B Phys Biol Sci. 2017;93(10):757-771. doi: 10.2183/pjab.93.048.
9
Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease.轻度认知障碍和阿尔茨海默病的黄斑微血管改变。
J Neuroophthalmol. 2018 Sep;38(3):292-298. doi: 10.1097/WNO.0000000000000580.
10
Alzheimer's disease prevention: from risk factors to early intervention.阿尔茨海默病的预防：从危险因素到早期干预。
Alzheimers Res Ther. 2017 Sep 12;9(1):71. doi: 10.1186/s13195-017-0297-z.