Saturio Silvia, Nogacka Alicja M, Alvarado-Jasso Guadalupe M, Salazar Nuria, de Los Reyes-Gavilán Clara G, Gueimonde Miguel, Arboleya Silvia
Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA-CSIC), 33300 Villaviciosa, Spain.
Diet, Human Microbiota and Health Group, Institute of Health Research of the Principality of Asturias (ISPA), 33011 Oviedo, Spain.
Microorganisms. 2021 Nov 23;9(12):2415. doi: 10.3390/microorganisms9122415.
Bifidobacteria are among the predominant microorganisms during infancy, being a dominant microbial group in the healthy breastfed infant and playing a crucial role in newborns and infant development. Not only the levels of the genus but also the profile and quantity of the different bifidobacterial species have been demonstrated to be of relevance to infant health. Although no definitive proof is available on the causal association, reduced levels of bifidobacteria are perhaps the most frequently observed alteration of the intestinal microbiota in infant diseases. Moreover, strains have been extensively studied by their probiotic attributes. This review compiles the available information about bifidobacterial composition and function since the beginning of life, describing different perinatal factors affecting them, and their implications on different health alterations in infancy. In addition, this review gathers exhaustive information about pre-clinical and clinical studies with strains as probiotics in neonates.
双歧杆菌是婴儿期的主要微生物之一，是健康母乳喂养婴儿中的优势微生物群，在新生儿和婴儿发育中起关键作用。不仅该属的水平，而且不同双歧杆菌物种的分布和数量都已被证明与婴儿健康相关。尽管尚无因果关联的确切证据，但双歧杆菌水平降低可能是婴儿疾病中最常观察到的肠道微生物群改变。此外，双歧杆菌菌株已因其益生菌特性而得到广泛研究。本综述汇编了自生命开始以来有关双歧杆菌组成和功能的现有信息，描述了影响它们的不同围产期因素，以及它们对婴儿期不同健康改变的影响。此外，本综述收集了关于双歧杆菌菌株作为新生儿益生菌的临床前和临床研究的详尽信息。
