人膀胱癌细胞系T-24分泌一种人B细胞分化因子。
The human bladder carcinoma line T-24 secretes a human B-cell differentiation factor.
作者信息
Christie J F, Gallagher G, Stimson W H
出版信息
Immunology. 1987 Mar;60(3):467-9.
Abstract
The effect of a B-cell differentiation factor (BCDF) found in the supernatant of the human bladder carcinoma cell line T-24 (T-24.BCDF) was assessed using the human lymphoblastoid line CESS (Muraguchi et al., 1981) and TPA-stimulated human B-CLL B cells. This T-24.BCDF was shown to cause both these cell types to secrete immunoglobulin, and therefore indicates that culture supernatants from this bladder carcinoma line contain a potent differentiation factor for human B cells.
摘要
利用人淋巴母细胞系CESS（村口等人，1981年）和经佛波酯（TPA）刺激的人B细胞慢性淋巴细胞白血病（B-CLL）B细胞，评估了在人膀胱癌细胞系T-24的上清液中发现的一种B细胞分化因子（BCDF，即T-24.BCDF）的作用。结果显示，这种T-24.BCDF可使这两种细胞类型分泌免疫球蛋白，因此表明该膀胱癌细胞系的培养上清液中含有一种对人B细胞有强效作用的分化因子。
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