Dureux J B, Canton P, Pecqueux J L, Belleville F, Biava M F, Chanteclair G
Pathol Biol (Paris). 1977 Dec;25(10):699-703.
In order to avoid other antibiotics which interfere with plasma and CSF level determination of a given antibiotic the authors use a chemical method of established specificity. 15 patients presenting with purulent meningitis were given a standard daily dose of metampicillin and divided into 3 groups of 5. On days 2, 4 and 6 after onset of disease plasma and CSF specimens were taken at respectively 1, 2 or 4 hours following metampicillin I.V. injection according to patient group. All patients were cured between days 7 and 21 of therapy. Tolerance was good.
--there was no correlation between dose injected and plasma level of drug,--CSF distribution of metampicillin was good and stayed identical throughout the disease period,--peak CSF drug level was delayed as compared to plasma level, occurring more than 4 hours after I.V. injection of metampicillin.
为避免使用其他干扰特定抗生素血浆和脑脊液水平测定的抗生素，作者采用了一种具有既定特异性的化学方法。15例化脓性脑膜炎患者接受了标准日剂量的甲氧苄青霉素，并分为3组，每组5人。在疾病发作后的第2、4和6天，根据患者分组，在静脉注射甲氧苄青霉素后1、2或4小时分别采集血浆和脑脊液标本。所有患者在治疗的第7至21天之间治愈。耐受性良好。
——注射剂量与药物血浆水平之间无相关性，——甲氧苄青霉素在脑脊液中的分布良好，且在整个疾病期间保持一致，——脑脊液药物峰值水平比血浆水平延迟，在静脉注射甲氧苄青霉素后4小时以上出现。
