Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, Guangdong, People's Republic of China.
Key Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Hubei Engineering Research Center for Advanced Fine Chemicals, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, Hubei, 430205, People's Republic of China.
Cancer Lett. 2022 Feb 28;527:164-173. doi: 10.1016/j.canlet.2021.12.019. Epub 2021 Dec 21.
As the downstream effectors of Hippo pathway, YAP/TAZ are identified to participate in organ growth, regeneration and tumorigenesis. However, owing to lack of a DNA-binding domain, YAP/TAZ usually act as coactivators and cooperate with other transcription factors or partners to mediate their transcriptional outputs. In this article, we first present an overview of the core components and the upstream regulators of Hippo-YAP/TAZ signaling in mammals, and then systematically summarize the identified transcription factors or partners that are responsible for the downstream transcriptional output of YAP/TAZ in various cancers.
作为 Hippo 通路的下游效应物，YAP/TAZ 被鉴定参与器官生长、再生和肿瘤发生。然而，由于缺乏 DNA 结合结构域，YAP/TAZ 通常作为共激活因子与其他转录因子或伴侣合作，以介导其转录输出。在本文中，我们首先概述了哺乳动物 Hippo-YAP/TAZ 信号通路的核心成分和上游调节剂，然后系统总结了在各种癌症中负责 YAP/TAZ 下游转录输出的已鉴定转录因子或伴侣。
