Du Licheng, Hu Xueting, Zhang Beibei, Miao Xiaqi, Wang Jianing, Shen Jiamin, Ding Keke, Zeng Tian, Sun Fangyue, Yang Hong, Lin Hai
Department of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, NO.108 Wansong Road, Wenzhou, 325000, Zhejiang, China.
School of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Diabetol Metab Syndr. 2021 Dec 24;13(1):151. doi: 10.1186/s13098-021-00772-y.
We aimed to investigate the role of platelet-to-lymphocyte ratio (PLR) in cognitive decline in patients with type 2 diabetes mellitus (T2DM).
A total number of 261 T2DM patients were enrolled in this study. The T2DM patients were divided into two groups according to the median of PLR (PLR < 96.5, n = 130; PLR ≥ 96.5, n = 131). Cognitive impairment was defined as Mini-mental State Examination score ≤ 26. Student's t test and Chi-square test were used to test the difference between the groups, and logistics regression analysis were performed to verify whether high PLR was an independent factor for cognitive impairment.
T2DM patients with cognitive impairment had significantly higher PLR level when compared with the simple diabetes group (p = 0.003). Incidence of cognitive impairment was higher in the high PLR group, compared to low PLR group (p = 0.040). Multivariate logistic regression analysis suggested that PLR was a risk biomarker of cognitive decline in T2DM patients (odds ratio [OR] = 1.010, 95% CI: 1.001-1.018, p = 0.013).
We demonstrated that a higher PLR was associated with cognitive decline in T2DM patients. The PLR may help to identify high-risk patients in time and provide clues for further prevention of cognitive dysfunction in T2DM patients.
我们旨在研究血小板与淋巴细胞比值（PLR）在2型糖尿病（T2DM）患者认知功能下降中的作用。
本研究共纳入261例T2DM患者。根据PLR的中位数将T2DM患者分为两组（PLR < 96.5，n = 130；PLR≥96.5，n = 131）。认知障碍定义为简易精神状态检查表得分≤26。采用学生t检验和卡方检验来检验组间差异，并进行逻辑回归分析以验证高PLR是否为认知障碍的独立因素。
与单纯糖尿病组相比，伴有认知障碍的T2DM患者的PLR水平显著更高（p = 0.003）。高PLR组的认知障碍发生率高于低PLR组（p = 0.040）。多因素逻辑回归分析表明，PLR是T2DM患者认知功能下降的风险生物标志物（比值比[OR] = 1.010，95%可信区间：1.001 - 1.018，p = 0.013）。
我们证明较高的PLR与T2DM患者的认知功能下降有关。PLR可能有助于及时识别高危患者，并为进一步预防T2DM患者的认知功能障碍提供线索。
