Al-Thobity Ahmad M, Al-Khalifa Khalifa S, Gad Mohammed M, Al-Hariri Mohammed, Ali Aiman A, Alnassar Talal
Department of Substitutive Dental Sciences, College of Dentistry, University of Dammam, Dammam 32214, Saudi Arabia.
Department of Preventive Dental Sciences, College of Dentistry, University of Dammam, Dammam 32214, Saudi Arabia.
Int J Environ Res Public Health. 2017 Jul 8;14(7):743. doi: 10.3390/ijerph14070743.
adhesion and proliferation on denture bases may lead to denture stomatitis, which is a common and recurrent problem in denture wearers. The goal of this study was to assess the inhibitory effect of thymoquinone incorporated in the polymethyl methacrylate denture base material against . Eighty acrylic resin specimens were fabricated and divided into eight groups ( = 10) according to thymoquinone concentrations of 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, and 5% of acrylic powder. Two methods were used to evaluate the effect of thymoquinone on : the slide count and the serial dilution test. A multivariate analysis of variance (MANOVA) and the post-hoc Tukey's Honestly Significant Difference (HSD) test were performed to compare the difference of means between the observations taken at various intervals with baseline. The value was statistically significant at ≤0.05. According to the slide count and the serial dilution test, the mean number of adhered in the control group was 5436.9 ± 266 and 4691.4 ± 176.8; however, this number dramatically decreased to 0 ± 0 and 32.4 ± 1.7 in group 8 (concentration 5%). These results suggest that the incorporation of thymoquinone into the acrylic resin denture base material might be effective in preventing adhesion.
义齿基托上的黏附与增殖可能导致义齿性口炎，这是义齿佩戴者中常见且反复出现的问题。本研究的目的是评估掺入聚甲基丙烯酸甲酯义齿基托材料中的百里醌对……的抑制作用。制备了80个丙烯酸树脂标本，并根据丙烯酸粉末中百里醌浓度为0.5%、1%、1.5%、2%、2.5%、3%和5%分为八组（每组n = 10）。使用两种方法评估百里醌对……的作用：载玻片计数法和连续稀释试验。进行多变量方差分析（MANOVA）和事后检验的Tukey真实显著差异（HSD）检验，以比较不同时间间隔与基线时观察值之间的均值差异。P值在≤0.05时具有统计学意义。根据载玻片计数法和连续稀释试验，对照组中黏附的……平均数量分别为5436.9 ± 266和4691.4 ± 176.8；然而，在第8组（浓度5%）中，这个数字急剧下降到0 ± 0和32.4 ± 1.7。这些结果表明，将百里醌掺入丙烯酸树脂义齿基托材料中可能有效地防止……黏附。
