纯合子镰状细胞中氯喹和去乙基氯喹的蓄积增加。
Increased accumulation of chloroquine and desethylchloroquine in homozygous sickle cells.
作者信息
Orjih A U
出版信息
Bull World Health Organ. 1987;65(1):51-5.
Abstract
The effect of haemoglobin genotype on the level of chloroquine in the erythrocytes of homozygous sickle-cell (SS), normal (AA), and heterozygous (AS) subjects was investigated in vivo and in vitro. Two hours after a single oral dose of chloroquine its level in plasma was consistently lower in SS than in AA subjects. In contrast, its level in the erythrocytes was higher in SS than in AA subjects. Desethylchloroquine, a metabolite of chloroquine, was detected only in the erythrocytes of SS blood but was present in both the plasma and erythrocytes of AA blood. For the in vitro test, a 5% suspension of erythrocytes was incubated for 1 hour with a 2.06 mumol/l solution of chloroquine. The mean chloroquine distribution ratio (mumol chloroquine per kg erythrocytes:mumol chloroquine per litre medium) was 31.0, 3.5, and 2.7 for SS, AA, and AS erythrocytes, respectively. The results of the study indicate that haemoglobin genotype appears to influence the level of chloroquine in erythrocytes.
摘要
在体内和体外研究了血红蛋白基因型对纯合子镰状细胞（SS）、正常（AA）和杂合子（AS）受试者红细胞中氯喹水平的影响。单次口服氯喹两小时后，SS受试者血浆中氯喹水平始终低于AA受试者。相反，SS受试者红细胞中氯喹水平高于AA受试者。氯喹的代谢产物去乙基氯喹仅在SS血型的红细胞中检测到，但在AA血型的血浆和红细胞中均有存在。对于体外试验，将5%的红细胞悬液与2.06μmol/L的氯喹溶液孵育1小时。SS、AA和AS红细胞的平均氯喹分布比（每千克红细胞中氯喹的微摩尔数：每升培养基中氯喹的微摩尔数）分别为31.0、3.5和2.7。研究结果表明，血红蛋白基因型似乎会影响红细胞中氯喹的水平。
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