Koskinen M, Pöyhönen L, Seppänen S
Eur J Nucl Med. 1987;12(12):609-12. doi: 10.1007/BF00284536.
In this study, tomographic 201Tl washout analysis and coronary angiography were compared in 100 subjects. Seventeen subjects with healthy coronary arteries were used as reference material, on the basis of which the reference ranges for both the total washout of the heart muscle and the regional washout were determined. With angiography as the standard, this material yielded the following sensitivity values for total myocardial washout: 80% for three vessel proximal disease (n = 30), 64% for peripheral three vessel disease (n = 14), 66% for two vessel disease (n = 29) and 71% for single vessel disease (n = 17). Specificity in the reference group was 94%. Sensitivity values for regional washout were 83%, 93%, 59% and 71%, respectively. Stress ECG gave about 10% lower sensitivities. As far as sensitivity is concerned, however, visual assessment of tomographic images proved to be the best single method. In three patients, washout analysis was necessary to reveal evenly distributed ischemia and in seven cases it was essential in order to confirm an uncertain diagnosis; in other words, washout analysis had diagnostic value in 10 of the 100 patients.
在本研究中，对100名受试者的断层201铊洗脱分析和冠状动脉造影进行了比较。17名冠状动脉健康的受试者作为参考材料，据此确定了心肌总洗脱和局部洗脱的参考范围。以血管造影为标准，该材料得出的心肌总洗脱敏感性值如下：三支血管近端病变（n = 30）为80%，外周三支血管病变（n = 14）为64%，两支血管病变（n = 29）为66%，单支血管病变（n = 17）为71%。参考组的特异性为94%。局部洗脱的敏感性值分别为83%、93%、59%和71%。运动心电图的敏感性约低10%。然而，就敏感性而言，断层图像的视觉评估被证明是最佳的单一方法。在3例患者中，洗脱分析对于揭示均匀分布的缺血是必要的，在7例患者中，对于确诊不确定的诊断至关重要；换句话说，洗脱分析在100例患者中的10例具有诊断价值。
