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重组肿瘤坏死因子/恶病质素和白细胞介素1预处理可减少暴露于高氧环境下大鼠的肺氧化型谷胱甘肽蓄积、肺损伤及死亡率。

Recombinant tumor necrosis factor/cachectin and interleukin 1 pretreatment decreases lung oxidized glutathione accumulation, lung injury, and mortality in rats exposed to hyperoxia.

作者信息

White C W, Ghezzi P, Dinarello C A, Caldwell S A, McMurtry I F, Repine J E

出版信息

J Clin Invest. 1987 Jun;79(6):1868-73. doi: 10.1172/JCI113029.

DOI:10.1172/JCI113029
PMID:3495553
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC424531/
Abstract

Single, preexposure, parenteral injection with both recombinant tumor necrosis factor/cachectin (TNF/C) and interleukin-1 (IL-1) prolonged the survival of rats (144 +/- 9 h) in continuous hyperoxia (greater than 99% O2 at 1 atm) when compared with rats injected with boiled TNF/C and boiled IL-1 (61 +/- 2 h), TNF/C alone (61 +/- 2 h), IL-1 alone (62 +/- 2 h), or saline (64 +/- 3 h). After exposure to hyperoxia for 52 h, pleural effusion volume, pulmonary artery pressure, total pulmonary resistance, and lung morphologic damage were decreased in those rats given TNF/C and IL-1 as compared with saline-injected rats. In parallel, ratios of reduced (GSH) to oxidized (GSSG) glutathione were greater (P less than 0.05) in lungs of TNF/C + IL-1-injected rats (91 +/- 20) than of saline-injected rats (30 +/- 4) that had been exposed to hyperoxia for 52 h. No differences were found in superoxide dismutase, glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase, or catalase activities in lungs of TNF/C + IL-1- or saline-treated, hyperoxia-exposed rats. Our results indicate that pretreatment with TNF/C and IL-1 favorably altered lung glutathione redox status, decreased lung injury, and enhanced survival of rats exposed to hyperoxia.

摘要

与注射煮沸的肿瘤坏死因子/恶病质素（TNF/C）和煮沸的白细胞介素-1（IL-1）的大鼠（61±2小时）、单独注射TNF/C的大鼠（61±2小时）、单独注射IL-1的大鼠（62±2小时）或注射生理盐水的大鼠（64±3小时）相比，单次暴露前经肠胃外注射重组肿瘤坏死因子/恶病质素（TNF/C）和白细胞介素-1（IL-1）可延长持续高氧环境（1个大气压下氧气含量大于99%）中大鼠的存活时间（144±9小时）。在暴露于高氧环境52小时后，与注射生理盐水的大鼠相比，给予TNF/C和IL-1的大鼠胸腔积液量、肺动脉压、总肺阻力和肺形态损伤均有所降低。同时，暴露于高氧环境52小时的TNF/C + IL-1注射组大鼠肺组织中还原型（GSH）与氧化型（GSSG）谷胱甘肽的比例（91±20）高于注射生理盐水的大鼠（30±4）（P<0.05）。在暴露于高氧环境的TNF/C + IL-1或生理盐水处理组大鼠的肺组织中，超氧化物歧化酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶、葡萄糖-6-磷酸脱氢酶或过氧化氢酶的活性未发现差异。我们的结果表明，用TNF/C和IL-1进行预处理可有利地改变肺组织谷胱甘肽的氧化还原状态，减少肺损伤，并提高暴露于高氧环境的大鼠的存活率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e50/424531/8eb419116a3a/jcinvest00117-0333-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e50/424531/29e76be3adc2/jcinvest00117-0333-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e50/424531/e777230ec861/jcinvest00117-0333-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e50/424531/e70be800bb4f/jcinvest00117-0333-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e50/424531/8eb419116a3a/jcinvest00117-0333-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e50/424531/29e76be3adc2/jcinvest00117-0333-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e50/424531/e777230ec861/jcinvest00117-0333-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e50/424531/e70be800bb4f/jcinvest00117-0333-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e50/424531/8eb419116a3a/jcinvest00117-0333-d.jpg

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