SUMO4 M55V和-94ins/del基因变异与2型糖尿病的关联。
Association of SUMO4 M55V and -94ins/del gene variants with type-2 diabetes.
作者信息
Sozen Seyma, Horozoglu Cem, Bireller Elif Sinem, Karaali Zeynep, Cakmakoglu Bedia
机构信息
Department of Molecular Medicine, Institute for Experimental Medicine Research, Istanbul University, Istanbul, Turkey.
Department of Internal Medicine, Haseki Training and Research Hospital, Istanbul, Turkey.
出版信息
In Vivo. 2014 Sep-Oct;28(5):919-23.
AIM
There are two different types of diabetes mellitus, type 1 and type 2, with still unclear molecular mechanisms. In the present study, we aimed to investigate the role of small ubiquitin-like modifier 4 (SUMO4) M55V and nuclear factor kappa B1 (NFKB1)-94del/ins in type-2 diabetes mellitus.
MATERIALS AND METHODS
We analyzed SUMO4 M55V and NFKB1-94del/ins variants in 104 patients with type-2 diabetes and 124 healthy controls using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques.
RESULTS
The number of SUMO4 M55V MM genotype and M allele carriers was significantly higher in patients compared to the control group; however, no efficiency results were found related to NFKB1-94del/ins polymorphism.
CONCLUSION
It was found that SUMO4 M55V polymorphism and type-2 diabetes were significantly associated with a possible SUMO4 region to type-2 diabetes susceptibility. This preliminary study showed that the distribution of SUMO4 M55V and type-2 diabetes mellitus in Turkish patients may form the basis of future research.
目的
糖尿病有1型和2型两种不同类型，其分子机制仍不清楚。在本研究中，我们旨在探究小泛素样修饰物4（SUMO4）M55V和核因子κB1（NFKB1）-94del/ins在2型糖尿病中的作用。
材料与方法
我们使用聚合酶链反应（PCR）和限制性片段长度多态性（RFLP）技术，对104例2型糖尿病患者和124名健康对照者的SUMO4 M55V和NFKB1-94del/ins变异进行了分析。
结果
与对照组相比，患者中SUMO4 M55V MM基因型和M等位基因携带者的数量显著更高；然而，未发现与NFKB1-94del/ins多态性相关的有效结果。
结论
发现SUMO4 M55V多态性与2型糖尿病显著相关，可能存在一个SUMO4区域与2型糖尿病易感性相关。这项初步研究表明，土耳其患者中SUMO4 M55V与2型糖尿病的分布情况可能为未来的研究奠定基础。
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