Levine S, Saltzman A
J Pharmacol Methods. 1987 Apr;17(2):173-8. doi: 10.1016/0160-5402(87)90028-3.
Tin powder, injected into both hindfeet of rats, caused intense proliferation of the plasma cell series in the draining lymph nodes. The hyperplasia was evaluated by weight and by histology of the nodes. This simple, rapidly executed model was used to evaluate the delivery of locally injected cytotoxic drugs to regional lymph nodes. Inhibition of hyperplasia was compared to both internal controls (contralateral node) and external controls. Mitoxantrone and methotrexate, injected locally according to certain doses and schedules, were effective in reducing the lymph node hyperplasia with little or no systemic effects. This model should assist in the evaluation of drugs, schedules, and adjuvants that might be used in the regional treatment of lymph node hyperplasia or metastic neoplasia.
将锡粉注射到大鼠的双后足，可导致引流淋巴结中浆细胞系列的强烈增殖。通过淋巴结重量和组织学评估增生情况。这个简单、实施迅速的模型用于评估局部注射的细胞毒性药物向区域淋巴结的递送。将增生的抑制情况与内部对照（对侧淋巴结）和外部对照进行比较。按照一定剂量和方案局部注射米托蒽醌和甲氨蝶呤，可有效减轻淋巴结增生，且几乎没有或没有全身效应。该模型应有助于评估可能用于区域治疗淋巴结增生或转移性肿瘤的药物、方案和佐剂。
