锡盐可抑制Lewis大鼠浆细胞对金属锡的反应。
Tin salts prevent the plasma cell response to metallic tin in Lewis rats.
作者信息
Levine S, Sowinski R
出版信息
Toxicol Appl Pharmacol. 1983 Mar 30;68(1):110-5. doi: 10.1016/0041-008x(83)90359-9.
Inoculation of metallic tin powder produced marked proliferation of plasma cells and Russell body cells in draining lymph nodes. Prior, but not concurrent, administration of a soluble tin salt in the drinking water prevented the plasma cell hyperplasia. Various Na, Zn, Ag, and Cu salts were not inhibitory. The inhibitory effect of tin salts was detected as long as 2 months after the pretreatment was stopped. If the plasma cell response to metallic tin were due to an immunologic reaction, then the inhibition by a soluble tin salt may be a form of immunologic tolerance.
接种金属锡粉可使引流淋巴结中的浆细胞和拉塞尔小体细胞显著增殖。事先（而非同时）在饮用水中给予可溶性锡盐可预防浆细胞增生。各种钠、锌、银和铜盐均无抑制作用。在停止预处理后长达2个月仍可检测到锡盐的抑制作用。如果浆细胞对金属锡的反应是由于免疫反应，那么可溶性锡盐的抑制作用可能是一种免疫耐受形式。
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