Levine S, Saltzman A
Pathology Department, New York Medical College, Valhalla 10595.
Biol Trace Elem Res. 1991 Feb;28(2):165-72. doi: 10.1007/BF02863082.
Injection of metallic tin powder causes intense proliferation of plasma cells in draining lymph nodes of Lewis rats. Pretreatment orally with soluble tin salts prevents this response to subsequently injected metallic tin. In the present work, pretreatment with tin salts by parenteral injection was just as effective as addition to the drinking water. This new approach made the following experiments possible. Poorly soluble tin compounds were found to be inhibitory when injected parenterally. Tin salts injected parenterally into one of two rats joined in parabiotic union prevented the plasma cell response to metallic tin in both parabionts. The transfer of the inhibitory effect via the cross-circulating blood represents significant progress toward understanding the mechanisms involved. The evidence suggests the possibility that tin salts elicit an intermediary substance or process that is responsible for inhibition of the plasma cell response to metallic tin.
注射金属锡粉会导致Lewis大鼠引流淋巴结中的浆细胞大量增殖。口服可溶性锡盐进行预处理可防止对随后注射的金属锡产生这种反应。在本研究中，通过肠胃外注射用锡盐进行预处理与添加到饮用水中一样有效。这种新方法使以下实验成为可能。发现难溶性锡化合物经肠胃外注射时具有抑制作用。将锡盐肠胃外注射到联体的两只大鼠中的一只体内，可防止两只联体大鼠对金属锡产生浆细胞反应。通过交叉循环血液传递抑制作用代表了在理解其中涉及的机制方面取得的重大进展。证据表明，锡盐可能引发一种中间物质或过程，该物质或过程负责抑制对金属锡的浆细胞反应。
