Levine S, Saltzman A
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
Biol Trace Elem Res. 1996 Jun;52(3):303-8. doi: 10.1007/BF02789171.
Metallic tin powder, injected into Lewis rats obtained from three different sources, caused enlargement of the regional draining lymph nodes. The histopathology featured epithelioid cell granulomas around phagocytosed particles of tin and an intense hyperplasia of plasma cells. The same material injected into August rats enlarged the lymph nodes but the enlargement was caused by granulomas without a major concomitant plasma cell response. In most other strains, tin produced less lymph node enlargement and the plasma cell response was minimal. However, F1 hybrids of Lewis rats with either the August, Brown-Norway (BN), or Dark Agouti (DA) strains developed plasma cell hyperplasia similar to that seen in the parental Lewis strain. The response to tin was the same whether the tin was injected into the feet or into the peritoneal cavity. Thus, the lymph node response to metallic tin varied from a slight, banal response to insoluble foreign particles, to an exuberant granulomatous hyperplasia, to an intense plasmacellular hyperplasia, depending on the genetic characteristics of the subjects.
将金属锡粉注射到从三个不同来源获得的刘易斯大鼠体内，会导致局部引流淋巴结肿大。组织病理学特征为吞噬锡颗粒周围出现上皮样细胞肉芽肿以及浆细胞强烈增生。将相同物质注射到奥古斯特大鼠体内会使淋巴结肿大，但肿大是由肉芽肿引起的，且没有主要的伴随浆细胞反应。在大多数其他品系中，锡引起的淋巴结肿大较少，浆细胞反应也很轻微。然而，刘易斯大鼠与奥古斯特、棕色挪威（BN）或深色刺豚鼠（DA）品系的F1杂种出现了与亲代刘易斯品系相似的浆细胞增生。无论锡是注射到足部还是腹腔，对锡的反应都是相同的。因此，根据实验对象的遗传特征，对金属锡的淋巴结反应从对不溶性异物颗粒的轻微、平淡反应到旺盛的肉芽肿增生，再到强烈的浆细胞增生各不相同。
