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猪RGS16基因多态性与自然感染约克夏猪中猪圆环病毒病毒载量的遗传关联

Genetic association of polymorphisms in porcine RGS16 with porcine circovirus viral load in naturally infected Yorkshire pigs.

作者信息

Lee Seung-Hoon, Lim Kyu-Sang, Hong Ki-Chang, Kim Jun-Mo

机构信息

Division of Biotechnology, College of Life Science, Korea University, Seoul 02841, Korea.

Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, Korea.

出版信息

J Anim Sci Technol. 2021 Nov;63(6):1223-1231. doi: 10.5187/jast.2021.e105. Epub 2021 Nov 30.

DOI:10.5187/jast.2021.e105
PMID:34957439
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8672253/
Abstract

Regulator of G protein signaling 16 () is known to be associated with porcine circovirus type 2 (PCV2). PCV2 associated disease (PCVAD) is a serious problem in the swine industry. The representative symptoms of PCVAD are high viral titer proliferation and decreased average daily gain. In this study, we identified single nucleotide polymorphisms (SNPs) in the region, including the upstream region. Of the 22 identified SNPs, rs332913874, rs326071195, and rs318298586 were genotyped in 142 Yorkshire pigs. These SNPs were significantly associated with the PCV2 viral load. Moreover, the haplotype combination was also related to the PCV2 viral load. The haplotype and diplotype analysis also had a significant difference with the PCV2 viral load. Taken together, our results suggest that SNPs considerably affect the PCV2 viral load.

摘要

已知G蛋白信号调节因子16（）与猪圆环病毒2型（PCV2）有关。PCV2相关疾病（PCVAD）是养猪业中的一个严重问题。PCVAD的典型症状是病毒滴度高增殖和平均日增重下降。在本研究中，我们鉴定了该区域（包括上游区域）的单核苷酸多态性（SNP）。在鉴定出的22个SNP中，对142头约克夏猪的rs332913874、rs326071195和rs318298586进行了基因分型。这些SNP与PCV2病毒载量显著相关。此外，单倍型组合也与PCV2病毒载量有关。单倍型和双倍型分析与PCV2病毒载量也有显著差异。综上所述，我们的结果表明SNP对PCV2病毒载量有很大影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb1e/8672253/89a57f392862/jast-63-6-1223-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb1e/8672253/89a57f392862/jast-63-6-1223-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb1e/8672253/89a57f392862/jast-63-6-1223-g1.jpg

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