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脑室内注射蛋白质合成抑制剂茴香霉素对家兔解热反应的抑制作用

Suppression of antipyretic response in rabbits by intraventricular protein synthesis inhibitor, anisomycin.

作者信息

Morimoto A, Nakamori T, Watanabe T, Sakata Y, Murakami N

出版信息

Pflugers Arch. 1987 Apr;408(4):414-6. doi: 10.1007/BF00581138.

DOI:10.1007/BF00581138
PMID:3495780
Abstract

Fevers induced by intravenous injection of endogenous pyrogen (EP) and intraventricular prostaglandin E2 (PGE2) were significantly prolonged when protein synthesis inhibitor, anisomycin was administrated intraventricularly 30 min before or 1 hr after injection of EP or PGE2. The present results show that protein synthesis in the central nervous system is involved in the development of antipyresis.

摘要

当在静脉注射内源性致热原（EP）和脑室内注射前列腺素E2（PGE2）前30分钟或注射后1小时脑室内给予蛋白质合成抑制剂茴香霉素时，由它们引起的发热会显著延长。目前的结果表明，中枢神经系统中的蛋白质合成参与了退热作用的产生。

相似文献

1
Suppression of antipyretic response in rabbits by intraventricular protein synthesis inhibitor, anisomycin.脑室内注射蛋白质合成抑制剂茴香霉素对家兔解热反应的抑制作用
Pflugers Arch. 1987 Apr;408(4):414-6. doi: 10.1007/BF00581138.
2
The effects of the protein synthesis inhibitor anisomycin on the febrile responses to intracerebroventricular injections of bacterial pyrogen, arachidonic acid and prostaglandin E2.蛋白质合成抑制剂茴香霉素对脑室内注射细菌致热原、花生四烯酸和前列腺素E2所引起发热反应的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1987 Sep;336(3):332-41. doi: 10.1007/BF00172687.
3
Inhibition of brain protein synthesis suppresses the release of prostaglandin E2 in febrile rabbits.抑制脑蛋白质合成可抑制发热家兔中前列腺素E2的释放。
Brain Res Bull. 1984 Aug;13(2):335-8. doi: 10.1016/0361-9230(84)90135-7.
4
Further observations on the suppression of fever in rabbits by intracerebral action of anisomycin.关于茴香霉素脑内作用对家兔发热抑制的进一步观察
J Physiol. 1982 Jan;322:441-5. doi: 10.1113/jphysiol.1982.sp014047.
5
Multiple control of fever production in the central nervous system of rabbits.家兔中枢神经系统中发热产生的多重调控
J Physiol. 1988 Mar;397:269-80. doi: 10.1113/jphysiol.1988.sp017000.
6
Fever produced by intrahypothalamic pyrogen: effect of protein synthesis inhibition by anisomycin.下丘脑内源性致热原引起的发热：茴香霉素对蛋白质合成抑制的影响
Brain Res Bull. 1979 Nov-Dec;4(6):741-5. doi: 10.1016/0361-9230(79)90007-8.
7
Is the central arachidonic acid cascade system involved in the development of acute-phase response in rabbits?兔急性期反应的发生是否涉及中枢花生四烯酸级联系统？
J Physiol. 1988 Mar;397:281-9. doi: 10.1113/jphysiol.1988.sp017001.
8
Suppression of fever in rabbits by a protein synthesis inhibitor, anisomycin.蛋白质合成抑制剂茴香霉素对家兔发热的抑制作用
J Physiol. 1980 Aug;305:337-44. doi: 10.1113/jphysiol.1980.sp013367.
9
Fever induced in rabbits by intraventricular injection of rabbit and human serum albumin.通过脑室内注射兔和人血清白蛋白在兔身上诱导发热。
J Physiol. 1987 Sep;390:137-44. doi: 10.1113/jphysiol.1987.sp016690.
10
Pattern differences in experimental fevers induced by endotoxin, endogenous pyrogen, and prostaglandins.内毒素、内源性致热原和前列腺素所致实验性发热的热型差异
Am J Physiol. 1988 Apr;254(4 Pt 2):R633-40. doi: 10.1152/ajpregu.1988.254.4.R633.

本文引用的文献

1
Pathogenesis of fever.发热的发病机制。
Physiol Rev. 1960 Jul;40:580-646. doi: 10.1152/physrev.1960.40.3.580.
2
Suppression of fever in rabbits by a protein synthesis inhibitor, anisomycin.蛋白质合成抑制剂茴香霉素对家兔发热的抑制作用
J Physiol. 1980 Aug;305:337-44. doi: 10.1113/jphysiol.1980.sp013367.
3
The effects of intracerebroventricular cycloheximide on protein synthesis and fever in rabbits.脑室内注射放线菌酮对家兔蛋白质合成和发热的影响。
Br J Pharmacol. 1981 May;73(1):6-8. doi: 10.1111/j.1476-5381.1981.tb16763.x.
4
Inhibition, by trichothecene antibiotics, of brain protein synthesis and fever in rabbits.单端孢霉烯族抗生素对家兔脑蛋白质合成及发热的抑制作用。
J Physiol. 1982 Jan;322:447-55. doi: 10.1113/jphysiol.1982.sp014048.
5
Further observations on the suppression of fever in rabbits by intracerebral action of anisomycin.关于茴香霉素脑内作用对家兔发热抑制的进一步观察
J Physiol. 1982 Jan;322:441-5. doi: 10.1113/jphysiol.1982.sp014047.
6
Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized cats and rabbits.将A、E和F系列前列腺素注入未麻醉的猫和兔的第三脑室对体温的影响。
J Physiol. 1971 Oct;218(2):325-36. doi: 10.1113/jphysiol.1971.sp009620.
7
Rat endogenous pyrogen and fever.
Am J Physiol. 1986 May;250(5 Pt 2):R776-82. doi: 10.1152/ajpregu.1986.250.5.R776.
8
Fever produced by intrahypothalamic pyrogen: effect of protein synthesis inhibition by anisomycin.下丘脑内源性致热原引起的发热：茴香霉素对蛋白质合成抑制的影响
Brain Res Bull. 1979 Nov-Dec;4(6):741-5. doi: 10.1016/0361-9230(79)90007-8.
9
Evidence supporting a role for endogenous vasopressin in natural suppression of fever in the sheep.支持内源性血管加压素在绵羊自然退热中发挥作用的证据。
J Physiol. 1979 Oct;295:33-45. doi: 10.1113/jphysiol.1979.sp012953.