蛋白质合成抑制剂茴香霉素对家兔发热的抑制作用
Suppression of fever in rabbits by a protein synthesis inhibitor, anisomycin.
作者信息
Cranston W I, Hellon R F, Townsend Y
出版信息
J Physiol. 1980 Aug;305:337-44. doi: 10.1113/jphysiol.1980.sp013367.
Abstract
- The protein synthesis inhibitor, anisomycin, was given into the cerebral ventricles of rabbits as a priming dose followed by a continuous infusion. Doses of 100, 200 and 300 microgram followed by infusions at 100, 200 and 300 microgram/hr inhibited the incorporation of [14C] leucine into hypothalamic protein by over 90%. 2. Injection and infusion of anisomycin (300 microgram) suppressed the febrile response to leucocyte (endogenous) pyrogen given into the ventricles (I.C.V.) or I.V. 3. Dialysis experiments showed that anisomycin did not combine irreversibly with leucocyte pyrogen. 4. Anisomycin did not interfere with thermoregulation in a cold environment. 5. It is concluded that pyrogenesis may involve a step which is dependent on synthesis of hypothalamic protein with a rapid turnover.
摘要
- 将蛋白质合成抑制剂茴香霉素作为起始剂量注入兔脑室，随后持续输注。剂量为100、200和300微克，随后分别以100、200和300微克/小时的速度输注，可使[14C]亮氨酸掺入下丘脑蛋白质的量减少90%以上。2. 注射和输注茴香霉素（300微克）可抑制脑室（脑室内）或静脉注射白细胞（内源性）致热原引起的发热反应。3. 透析实验表明，茴香霉素与白细胞致热原不会发生不可逆结合。4. 茴香霉素在寒冷环境中不干扰体温调节。5. 得出的结论是，发热机制可能涉及一个依赖于快速更新的下丘脑蛋白质合成的步骤。
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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