Zhou Qian, Tian Tian, Ni Jie, Zhao Xiaoheng, Li Hong, Yang Yili, Zhang Yumeng, Pan Jay
HEOA Group, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Health Development Research Center, Chengdu 610041, China.
Vaccines (Basel). 2021 Nov 25;9(12):1398. doi: 10.3390/vaccines9121398.
The outbreak of coronavirus disease 2019 (COVID-19) has led to numerous tragic deaths all over the world. Great efforts have been made by worldwide nations for COVID-19 targeted vaccine development since the disease outbreak. In January 2021, the Chinese government started to provide free vaccination among nationwide communities, which was optional for citizens. As no evidence has been provided so far regarding COVID-19 vaccination acceptance since the initiation of nationwide vaccination, this study aims to investigate COVID-19 vaccination acceptance among Chinese citizens as well as its associated factors as an attempt to bridge such gap embedded in the current literature. An anonymous cross-sectional study was conducted online in March and April 2021 among adults, with the survey questionnaire designed based on the framework of the health belief model (HBM). Information on socio-demographics, risk perception, past pandemic-related experience, awareness of vaccination as well as acceptance of COVID-19 vaccination were collected. Chi-squared test and multi-level regression were performed to distinguish the acceptance between different groups as well as to identify the significant predictors. A total of 3940 participants completed the survey, with 90.6% of the participants reporting strong willingness to get vaccinated. A list of factors were found to be significantly associated with individuals' acceptance of vaccination, including the region of residence, ethnicity, annual income, whether or not they had experienced a major pandemic event in the past, risk perception of the COVID-19 as well as the awareness of receiving vaccination. Safety concerns about the vaccine (27.7%), concerns about receiving vaccination immediately after newly developed vaccines were released into the market (22.4%) as well as concerns about the potential side effects induced by vaccination (22.1%) were identified as the primary reasons of residents' resistance against vaccination. Overall, residents demonstrated strong willingness to receive vaccination against COVID-19 in China. However, the improvement of vaccination-related knowledge among Chinese residents should be highlighted as a critical strategy to facilitate the penetration of nationwide vaccination in order to ultimately achieve the establishment of herd immunity in China.
2019年冠状病毒病（COVID-19）疫情已在全球导致无数悲惨死亡。自该疾病爆发以来，世界各国为研发针对COVID-19的疫苗付出了巨大努力。2021年1月，中国政府开始在全国社区提供免费疫苗接种，公民可自愿选择。由于自全国疫苗接种开始以来，尚未有关于COVID-19疫苗接种接受情况的证据，本研究旨在调查中国公民对COVID-19疫苗的接受情况及其相关因素，以填补当前文献中的这一空白。2021年3月和4月，在成年人中开展了一项在线匿名横断面研究，调查问卷基于健康信念模型（HBM）框架设计。收集了社会人口统计学、风险认知、过去与疫情相关的经历、疫苗接种意识以及对COVID-19疫苗接种的接受情况等信息。进行了卡方检验和多水平回归分析，以区分不同群体之间的接受情况，并确定显著的预测因素。共有3940名参与者完成了调查，90.6%的参与者表示有强烈的接种意愿。发现一系列因素与个人的疫苗接种接受情况显著相关，包括居住地区、民族、年收入、过去是否经历过重大疫情事件、对COVID-19的风险认知以及疫苗接种意识。对疫苗安全性的担忧（27.7%）、对新研发疫苗上市后立即接种的担忧（22.4%）以及对疫苗接种可能产生的副作用的担忧（22.1%）被确定为居民抵制接种的主要原因。总体而言，中国居民表现出强烈的接种COVID-19疫苗的意愿。然而，应强调提高中国居民与疫苗接种相关的知识，这是促进全国疫苗接种普及的关键策略，以便最终在中国建立群体免疫。
