Sartaj Ali, Qamar Zufika, Qizilbash Farheen Fatima, Md Shadab, Alhakamy Nabil A, Baboota Sanjula, Ali Javed
Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Polymers (Basel). 2021 Dec 15;13(24):4400. doi: 10.3390/polym13244400.
This manuscript aims to provide the latest update on polymeric nanoparticle drug delivery system for breast cancer treatment after 2015 and how research-oriented it is based on the available research data. Therefore, the authors have chosen breast cancer which is the most frequent and common reason for mortality in women worldwide. The first-line treatment for breast cancer treatment is chemotherapy, apart from surgery, radiation and hormonal therapy. Chemotherapy is associated with lesser therapeutics and undesirable side effects and hence. In addition, drug resistance affects the therapeutic dose to the target site. Although various nano-based formulations have been developed for effective treatment, the polymeric nanoparticles effectively avoid the lacunae of conventional chemotherapy. There has been an effort made to understand the chemotherapy drugs and their conventional formulation-related problems for better targeting and effective drug delivery for breast cancer treatment. Thus, the polymeric nanoparticles as a strategy overcome the associated problems with resulting dose reduction, enhanced bioavailability, reduced side effects, etc. This present review has compiled the research reports published from 2015 to 2021 from different databases, such as PubMed, Google Scholar, ScienceDirect, which are related to breast cancer treatment in which the drug delivery of numerous chemotherapeutic agents alone or in combination, including phytoconstituents formulated into various polymer-based nanoparticles.
本手稿旨在提供2015年后用于乳腺癌治疗的聚合物纳米颗粒药物递送系统的最新进展，以及基于现有研究数据其研究的方向。因此，作者选择了乳腺癌，它是全球女性最常见的死亡原因。乳腺癌治疗的一线治疗方法是化疗，此外还有手术、放疗和激素治疗。化疗伴随着较少的治疗效果和不良副作用，因此。此外，耐药性会影响到达靶部位的治疗剂量。尽管已经开发了各种基于纳米的制剂用于有效治疗，但聚合物纳米颗粒有效地避免了传统化疗的缺陷。人们一直在努力了解化疗药物及其与传统制剂相关的问题，以便更好地靶向和有效地递送用于乳腺癌治疗的药物。因此，聚合物纳米颗粒作为一种策略克服了相关问题，从而减少了剂量、提高了生物利用度、减少了副作用等。本综述汇编了2015年至2021年从不同数据库（如PubMed、谷歌学术、ScienceDirect）发表的与乳腺癌治疗相关的研究报告，其中包括多种化疗药物单独或联合的药物递送，包括配制成各种基于聚合物的纳米颗粒的植物成分。
