National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, 38000, Pakistan.
Constituent College Pakistan Institute of Engineering and Applied Sciences, Faisalabad, Pakistan.
Curr Top Med Chem. 2022;22(13):1046-1067. doi: 10.2174/1568026622666211227151743.
The rapid emergence of multidrug-resistant bacterial strains highlights the need for the development of new antimicrobial compounds/materials to address associated healthcare challenges. Meanwhile, the adverse side effects of conventional antibiotics on human health urge the development of new natural product-based antimicrobials to minimize the side effects. In this respect, we concisely review the recent scientific contributions to develop natural product-based nano-antibiotics. The focus of the review is on the use of flavonoids, peptides, and cationic biopolymer functionalized metal/metal oxide nanoparticles as efficient tools to hit the MDR bacterial strains. It summarizes the most recent aspects of the functionalized nanoparticles against various pathogenic bacterial strains for their minimal inhibitory concentrations and mechanism of action at the cellular and molecular levels. In the end, the future perspectives to materialize the in vivo applications of nano-antimicrobials are suggested based on the available research.
耐药细菌菌株的迅速出现凸显了开发新的抗菌化合物/材料以应对相关医疗保健挑战的必要性。与此同时，传统抗生素对人类健康的不良副作用促使人们开发新的基于天然产物的抗菌药物，以最大程度减少副作用。在这方面，我们简要回顾了最近在开发基于天然产物的纳米抗生素方面的科学贡献。本综述的重点是使用黄酮类化合物、肽和阳离子生物聚合物功能化的金属/金属氧化物纳米颗粒作为有效工具来对抗多药耐药细菌菌株。它总结了功能化纳米颗粒针对各种致病性细菌菌株的最新方面，包括其最低抑菌浓度和在细胞和分子水平上的作用机制。最后，根据现有研究，提出了实现纳米抗菌剂体内应用的未来展望。
