Department of Dermatology & STD, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Dermatol Ther. 2022 Mar;35(3):e15288. doi: 10.1111/dth.15288. Epub 2022 Jan 18.
The disordered skin microbiome has been reported to contribute to the pathogenesis of acne vulgaris, for which benzoyl peroxide (BPO) has long been recommended as the first-line therapy. However, there are no data regarding the effect of BPO treatment on skin microbiota and the epidermal barrier in young adults with acne vulgaris. Thirty-three patients with acne vulgaris and 19 healthy controls were enrolled in the study. All patients received topical treatment with BPO 5% gel for 12 weeks. The epidermal barrier was analyzed at baseline and after treatment. Microbial diversity was analyzed using a high-throughput sequencing approach targeting the V3-V4 region of 16S rRNA genes. After receiving treatment with BPO, patients had significant improvement in their Global Acne Grading System (GAGS) score, porphyrin, and red areas (p < 0.05), and the presence of sebum, stratum corneum hydration (SCH), and transepidermal water loss (TEWL) increased (p < 0.05). When compared with baseline, microbial diversity was significantly reduced after treatment, as calculated by the goods coverage (p = 0.0017), Shannon (p = 0.0094), and Simpson (p = 0.0017) diversity indices. The prevalence of the genus Cutibacterium (before treatment: 5.64 [3.50, 7.78] vs. after treatment: 2.43 [1.81, 3.05], p = 0.011) was significantly reduced after treatment while Staphylococcus (before treatment: 43.80 [36.62, 50.98] vs. after treatment: 53.38 [44.88, 61.87], p = 0.075) tended to increase. The abundance of Staphylococcus was negatively associated with SCH (p = 0.008, r = -0.286). Despite its contribution to an improved GAGS score, BPO treatment for acne vulgaris may reduce microbial diversity and damage the epidermal barrier.
有研究报道，皮肤微生物组的失调与寻常痤疮的发病机制有关，为此过氧化苯甲酰（BPO）长期以来一直被推荐为一线治疗药物。然而，目前尚无关于 BPO 治疗对寻常痤疮年轻患者皮肤微生物组和表皮屏障影响的数据。本研究纳入了 33 例寻常痤疮患者和 19 名健康对照者。所有患者均接受了 5%过氧化苯甲酰凝胶外用治疗，为期 12 周。在基线和治疗后分析了表皮屏障。采用高通量测序方法，针对 16S rRNA 基因的 V3-V4 区，分析微生物多样性。接受 BPO 治疗后，患者的全球痤疮分级系统（GAGS）评分、卟啉和红斑区域显著改善（p<0.05），皮脂、角质层水分（SCH）和经皮水分丢失（TEWL）增加（p<0.05）。与基线相比，经治疗后，Goods 覆盖率（p=0.0017）、Shannon 指数（p=0.0094）和 Simpson 指数（p=0.0017）计算的微生物多样性显著降低。治疗后，表皮葡萄球菌属（治疗前：5.64[3.50，7.78] vs. 治疗后：2.43[1.81，3.05]，p=0.011）的流行率显著降低，而金黄色葡萄球菌（治疗前：43.80[36.62，50.98] vs. 治疗后：53.38[44.88，61.87]，p=0.075）则呈上升趋势。金黄色葡萄球菌的丰度与 SCH 呈负相关（p=0.008，r=-0.286）。尽管 BPO 治疗寻常痤疮可改善 GAGS 评分，但可能会降低微生物多样性并损害表皮屏障。
