Hsieh K H, Lue K H
J Clin Immunol. 1987 May;7(3):203-9. doi: 10.1007/BF00915725.
Augmented IgE production and increased infections are often seen in allergic patients. As monocytes (MN) and polymorphonuclear leukocytes (PMN) are involved in both immune regulation and inflammatory reaction, MN function in terms of monokine production stimulated with lipopolysaccharide (MN supernatant; MN-sup) and its biological activity and the response of PMN to MN-sup and recombinant interleukin-1 (rIL-1) regarding chemotactic activity and expression of IgG Fc receptor (FcR) were studied in 26 normal children and 28 new and 22 hyposensitized (HS) asthmatic children. The results showed the following. There was no difference in IL-1 production, as assayed by thymocyte proliferation, among the three groups. All MN-sup from the three groups could enhance IL-2 production, but that of new patients was less efficient. In the absence of PWM, MN-sup of new patients greatly augmented the production of IgG, IgA, IgM, and IgE, but that of HS patients could enhance only IgE synthesis. MN-sup of patients enhanced less efficiently the chemotactic activity and FcR expression of PMN from healthy volunteers, and PMN from asthmatics responded much less vigorously to rIL-1 regarding the above-mentioned functions. The number of PMN with membrane IL-1 was much lower in allergic patients. Thus the abnormal MN and PMN functions may be used to explain partly the augmented IgE production and increased infections in allergic patients.
在过敏患者中，常常可以看到免疫球蛋白E（IgE）产生增加以及感染增多。由于单核细胞（MN）和多形核白细胞（PMN）都参与免疫调节和炎症反应，因此，研究了26名正常儿童、28名初发哮喘儿童以及22名减敏（HS）哮喘儿童的MN功能（以脂多糖刺激产生的单核因子；MN上清液，MN-sup）及其生物学活性，以及PMN对MN-sup和重组白细胞介素-1（rIL-1）在趋化活性和IgG Fc受体（FcR）表达方面的反应。结果如下。通过胸腺细胞增殖检测，三组之间白细胞介素-1的产生没有差异。三组的所有MN-sup都能增强白细胞介素-2的产生，但初发患者的MN-sup效率较低。在没有美洲商陆有丝分裂原（PWM）的情况下，初发患者的MN-sup能极大地增加IgG、IgA、IgM和IgE的产生，但HS患者的MN-sup只能增强IgE的合成。患者的MN-sup增强健康志愿者PMN趋化活性和FcR表达的效率较低，并且哮喘患者的PMN对rIL-1在上述功能方面的反应要弱得多。过敏患者中膜表面有白细胞介素-1的PMN数量要低得多。因此，MN和PMN的异常功能可能部分解释了过敏患者中IgE产生增加和感染增多的现象。
