Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300350, China.
Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark.
AAPS PharmSciTech. 2021 Dec 28;23(1):41. doi: 10.1208/s12249-021-02200-w.
Drugs are referred to as drug nanocrystals when they exist as nanoscale crystal structures. This kind of nanocarrier has been widely utilized to increase the solubility and absorption for poorly aqueous soluble drugs after oral administration, or prolong the drug circulation when intravenous administration. The systemic cytotoxicity caused by antitumor drugs usually come from the nonspecific drug distribution. To solve the disadvantage of poor targetability, drug nanocrystals for tumor targeted delivery have been developed in recent years. In this review, the targeting mechanisms of various surface modified drug nanocrystals are introduced with the focus on passive targeting, active targeting and stimuli-responsive targeting in details. Function and application of common surface modified materials are also discussed.
当药物以纳米级晶体结构存在时，被称为药物纳米晶体。这种纳米载体已广泛用于提高口服后水溶性差的药物的溶解度和吸收度，或在静脉给药时延长药物循环时间。抗肿瘤药物引起的全身细胞毒性通常来自于非特异性药物分布。为了解决靶向性差的缺点，近年来已经开发了用于肿瘤靶向递送的药物纳米晶体。在这篇综述中，详细介绍了各种表面修饰的药物纳米晶体的靶向机制，重点介绍了被动靶向、主动靶向和刺激响应性靶向。还讨论了常见表面修饰材料的功能和应用。
