Gonzalez-Amaro R, Alcocer-Varela J, Alarcón-Segovia D
J Rheumatol. 1987 Apr;14(2):307-10.
We examined the baseline natural killer (NK) function and its modulation by interleukin-2 (IL-2) in 16 patients with dermatomyositis/polymyositis (DM/PM). Patients with active untreated disease had low baseline NK activity, while in patients with inactive and untreated disease, it was akin to the controls. Patient's cells with low NK activity responded less to IL-2 than those with normal NK activity. Studies at the single cell level revealed decreased target binding and killing cells with a normal recycling capacity. Our findings indicate an association between disease activity and decreased NK function in patients with DM/PM that could play a role in its association with malignancy.
我们检测了16例皮肌炎/多肌炎（DM/PM）患者的基线自然杀伤（NK）细胞功能及其受白细胞介素-2（IL-2）的调节情况。处于疾病活动期且未经治疗的患者基线NK活性较低，而处于疾病非活动期且未经治疗的患者，其NK活性与对照组相似。NK活性低的患者细胞对IL-2的反应低于NK活性正常的患者细胞。单细胞水平研究显示，具有正常再循环能力的细胞的靶细胞结合和杀伤能力降低。我们的研究结果表明，DM/PM患者的疾病活动与NK功能降低之间存在关联，这可能在其与恶性肿瘤的关联中起作用。
