Aarts Esther, Akkerman Agnes, Altgassen Mareike, Bartels Ronald, Beckers Becky, Bevelander Kirsten, Bijleveld Erik, Davidson Esmeralda Blaney, Boleij Annemarie, Bralten Janita, Cillessen Toon, Claassen Jurgen, Cools Roshan, Cornelissen Ineke, Dresler Martin, Eijsvogels Thijs, Faber Myrthe, Fernández Guillén, Figner Bernd, Fritsche Matthias, Füllbrunn Sascha, Gayet Surya, van Gelder Marleen M. H. J., van Gerven Marcel, Geurts Sabine, Greven Corina U., Groefsema Martine, Haak Koen, Hagoort Peter, Hartman Yvonne, van der Heijden Beatrice, Hermans Erno, Heuvelmans Vivian, Hintz Florian, den Hollander Janet, Hulsman Anneloes M., Idesis Sebastian, Jaeger Martin, Janse Esther, Janzing Joost, Kessels Roy P. C., Karremans Johan C., de Kleijn Willemien, Klein Marieke, Klumpers Floris, Kohn Nils, Korzilius Hubert, Krahmer Bas, de Lange Floris, van Leeuwen Judith, Liu Huaiyu, Luijten Maartje, Manders Peggy, Manevska Katerina, Marques José P., Matthews Jon, M. McQueen James, Medendorp Pieter, Melis René, Meyer Antje, Oosterman Joukje, Overbeek Lucy, Peelen Marius, Popma Jean, Postma Geert, Roelofs Karin, van Rossenberg Yvonne G. T., Schaap Gabi, Scheepers Paul, Selen Luc, Starren Marianne, Swinkels Dorine W., Tendolkar Indira, Thijssen Dick, Timmerman Hans, Tutunji Rayyan, Tuladhar Anil, Veling Harm, Verhagen Maaike, Verkroost Jasper, Vink Jacqueline, Vriezekolk Vivian, Vrijsen Janna, Vyrastekova Jana, van der Wal Selina, Willems Roel, Willemsen Arthur
Radboud University, Nijmegen, The Netherlands
Radboud University Medical Center, Nijmegen, The Netherlands
PLoS One. 2021 Dec 29;16(12):e0260952. doi: 10.1371/journal.pone.0260952. eCollection 2021.
The endeavor to understand the human brain has seen more progress in the last few decades than in the previous two millennia. Still, our understanding of how the human brain relates to behavior in the real world and how this link is modulated by biological, social, and environmental factors is limited. To address this, we designed the Healthy Brain Study (HBS), an interdisciplinary, longitudinal, cohort study based on multidimensional, dynamic assessments in both the laboratory and the real world. Here, we describe the rationale and design of the currently ongoing HBS. The HBS is examining a population-based sample of 1,000 healthy participants (age 30-39) who are thoroughly studied across an entire year. Data are collected through cognitive, affective, behavioral, and physiological testing, neuroimaging, bio-sampling, questionnaires, ecological momentary assessment, and real-world assessments using wearable devices. These data will become an accessible resource for the scientific community enabling the next step in understanding the human brain and how it dynamically and individually operates in its bio-social context. An access procedure to the collected data and bio-samples is in place and published on https://www.healthybrainstudy.nl/en/data-and-methods/access. Trail registration: https://www.trialregister.nl/trial/7955.
在过去几十年里，人类对大脑的探索取得的进展比此前两千年还要多。然而，我们对于人类大脑如何与现实世界中的行为相关联，以及这种联系如何受到生物、社会和环境因素调节的理解仍然有限。为了解决这一问题，我们设计了健康大脑研究（HBS），这是一项跨学科的纵向队列研究，基于实验室和现实世界中的多维动态评估。在此，我们描述当前正在进行的HBS的基本原理和设计。HBS正在对1000名健康参与者（年龄在30至39岁之间）进行基于人群的抽样研究，对他们进行一整年的全面研究。数据通过认知、情感、行为和生理测试、神经成像、生物采样、问卷调查、生态瞬时评估以及使用可穿戴设备进行的现实世界评估来收集。这些数据将成为科学界可获取的资源，有助于推动我们进一步了解人类大脑，以及它在生物社会环境中如何动态且个体地运作。已制定了获取所收集数据和生物样本的程序，并发布在https://www.healthybrainstudy.nl/en/data-and-methods/access上。试验注册：https://www.trialregister.nl/trial/7955。
