Rocha Marina Pereira, Amorim Juliana Mendes, Lima William Gustavo, Brito Júlio César Moreira, da Cruz Nizer Waleska Stephanie
Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, Minas Gerais, Brazil.
Fundação Ezequiel Dias FUNED, Belo Horizonte, MG, Brazil.
J Ethnopharmacol. 2022 Apr 6;287:114939. doi: 10.1016/j.jep.2021.114939. Epub 2021 Dec 26.
Apitherapy is a branch of traditional medicine that uses bee products to manage numerous diseases. In this context, the antiherpetic effect of these bee products has been demonstrated in some studies with some controversial results.
Thus, we conducted a systematic review and meta-analysis to compare the effectiveness of honey and propolis with acyclovir, the reference drug, in the treatment of cold sores and genital herpes.
The selection of eligible studies was conducted through the search in Pubmed/MEDLINE, Scopus, Cochrane Library, LILACS, and Electronic Scientific Library.
The search yielded 147 articles, of which nine were considered eligible for analysis. The analysis of these studies showed that the healing property of propolis is superior to that obtained for acyclovir (95% CI: 2.70 to 8.25; p = 0.0001). Furthermore, honey also presented a better healing effect than acyclovir against Herpes simplex virus-induced wounds (95% CI: 3.58 to -0.19; p = 0.03), inducing complete re-epithelization of herpetic lesions after 8 days, while for acyclovir, the healing time average was 9 days. It also provoked a similar reduction of pain caused by herpetic compared to acyclovir (95% CI: 2.27 to -0.42; p = 0.18).
Overall, these results confirm the use of honey and propolis as potent antiherpetic agents.
蜂疗是传统医学的一个分支，利用蜂产品治疗多种疾病。在此背景下，一些研究已证实这些蜂产品具有抗疱疹作用，但结果存在一定争议。
因此，我们进行了一项系统评价和荟萃分析，以比较蜂蜜和蜂胶与对照药物阿昔洛韦在治疗唇疱疹和生殖器疱疹方面的有效性。
通过检索PubMed/MEDLINE、Scopus、Cochrane图书馆、LILACS和电子科学图书馆来筛选合格的研究。
检索共得到147篇文章，其中9篇被认为符合分析条件。对这些研究的分析表明，蜂胶的愈合特性优于阿昔洛韦（95%置信区间：2.70至8.25；p = 0.0001）。此外，蜂蜜对单纯疱疹病毒引起的伤口也表现出比阿昔洛韦更好的愈合效果（95%置信区间：3.58至 -0.19；p = 0.03），能在8天后使疱疹性损伤完全重新上皮化，而阿昔洛韦的平均愈合时间为9天。与阿昔洛韦相比，它还能使疱疹引起的疼痛有类似程度的减轻（95%置信区间：2.27至 -0.42；p = 0.18）。
总体而言，这些结果证实了蜂蜜和蜂胶可作为有效的抗疱疹药物。
