Kobayashi H, Ohashi N, Watanabe Y, Mizukoshi K
ORL J Otorhinolaryngol Relat Spec. 1987;49(2):67-72. doi: 10.1159/000275909.
Patients treated with cisplatin were observed in an otoneurological study with special reference to cochlear and vestibular toxicity. Toxicity-related symptoms appeared to be almost all transient. As with leukopenia, hearing loss and dizziness often occurred after several weeks of administration. In the equilibrium examinations, some abnormal findings such as spontaneous nystagmus and positional nystagmus were seen. Caloric tests and body sway tests detected abnormal findings in the early stages of cisplatin-related vestibulotoxicity.
在一项耳神经学研究中观察了接受顺铂治疗的患者，特别关注耳蜗和前庭毒性。与毒性相关的症状似乎几乎都是短暂的。与白细胞减少症一样，听力损失和头晕常在给药几周后出现。在平衡检查中，发现了一些异常表现，如自发性眼球震颤和位置性眼球震颤。冷热试验和身体摇摆试验在顺铂相关前庭毒性的早期阶段检测到了异常表现。
