School of Advanced Sciences, Vellore Institute of Technology, Vellore, India.
Department of Radiation Oncology, Gleneagles Global Hospitals, Chennai, India.
Asian Pac J Cancer Prev. 2021 Dec 1;22(12):3933-3939. doi: 10.31557/APJCP.2021.22.12.3933.
This study intends at a dosimetric comparison of four different hybrid plans which is a combination of different radiation therapy techniques, for synchronous bilateral breast cancer (SBBC) irradiation using a hypofractionated dose regimen.
Four different hybrid techniques: 3DCRT+IMRT, 3DCRT+VMAT, IMRT+VMAT, and VMAT+IMRT were planned using computed tomography (CT) images of fifteen SBBC patients. All hybrid plans were generated using a hypofractionated dose prescription of 40.5 Gy in 15 fractions. 70% of the dose was planned with a base-dose component and the remaining 30% of the dose was planned with a hybrid component. The plans were evaluated based on the PTV and organs at risk (OARs) dosimetric parameter results and computed a plan quality score for each plan.
The results for PTV parameters have shown that the 3DCRT+VMAT and 3DCRT+IMRT plans were better than other plans. The 3DCRT±IMRT plan was provided better results for OARs, while IMRT±VMAT and VMAT+IMRT plans were increased the low dose volumes to the heart and lungs. The 3DCRT+VMAT plan was required less monitor units and treatment time compared to other plans.
The overall plan quality score that integrated the dosimetric parameters of PTV and OARs indicated that the 3DCRT+VMAT hybrid plan is superior for SBBC treatment.
本研究旨在对四种不同的混合计划进行剂量学比较，这些计划是不同放射治疗技术的组合，用于同步双侧乳腺癌（SBBC）照射，采用分次剂量方案。
对 15 例 SBBC 患者的 CT 图像进行了四种不同的混合技术：3DCRT+IMRT、3DCRT+VMAT、IMRT+VMAT 和 VMAT+IMRT 规划。所有混合计划均采用 40.5Gy 的分次剂量处方生成，15 个分数。70%的剂量用基础剂量成分计划，其余 30%的剂量用混合成分计划。根据 PTV 和危及器官（OAR）剂量学参数结果评估计划，并为每个计划计算计划质量评分。
PTV 参数的结果表明，3DCRT+VMAT 和 3DCRT+IMRT 计划优于其他计划。3DCRT±IMRT 计划为 OARs 提供了更好的结果，而 IMRT±VMAT 和 VMAT+IMRT 计划增加了心脏和肺部的低剂量体积。3DCRT+VMAT 计划比其他计划需要更少的监测单位和治疗时间。
综合考虑 PTV 和 OARs 剂量学参数的总体计划质量评分表明，3DCRT+VMAT 混合计划是治疗 SBBC 的首选。
