腹膜转移评分系统对预测晚期卵巢癌手术完全性的价值。
Scoring Systems of Peritoneal Dissemination for the Prediction of Operative Completeness in Advanced Ovarian Cancer.
机构信息
Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan.
Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan
出版信息
Anticancer Res. 2022 Jan;42(1):115-124. doi: 10.21873/anticanres.15465.
BACKGROUND/AIM: We investigated the predictive value of scoring systems of peritoneal disseminations for complete surgery (CS) at primary debulking surgery (PDS) in advanced ovarian cancer.
PATIENTS AND METHODS
We retrospectively enrolled eligible patients with clinical stages III or IVA selected for PDS from January 2015 to December 2019. Concern variables were predictive index value (PIV) and peritoneal cancer index (PCI) from operative and pathological reports. Primary endpoints were cutoffs to predict operative completeness using the receiver operating characteristic curve.
RESULTS
Among 111 patients, PIV ≥8 and PCI ≥13 were the best predictors of incomplete PDS, including optimal and suboptimal surgeries (AUC=0.821 and 0.855, respectively). CS rates in PIV ≤6 and PCI ≤12 were significantly higher than in PIV ≥8 (89.3% vs. 47.2%; p<0.05) and PCI ≥13 (90.9% vs. 41.2%: p<0.05).
CONCLUSION
PIV and PCI are potential predictors for CS at PDS.
背景/目的：我们研究了评分系统对晚期卵巢癌患者初次肿瘤细胞减灭术（PDS）中完全手术（CS）的预测价值。
患者与方法
我们回顾性纳入了 2015 年 1 月至 2019 年 12 月期间选择行 PDS 的临床分期为 III 期或 IVA 期的患者。观察变量为手术和病理报告中的预测指数值（PIV）和腹膜癌指数（PCI）。主要终点是使用受试者工作特征曲线预测手术完整性的截断值。
结果
在 111 例患者中，PIV≥8 和 PCI≥13 是不完全 PDS 的最佳预测因素，包括最佳和次优手术（AUC=0.821 和 0.855）。PIV≤6 和 PCI≤12 的 CS 率明显高于 PIV≥8（89.3% vs. 47.2%；p<0.05）和 PCI≥13（90.9% vs. 41.2%：p<0.05）。
结论
PIV 和 PCI 是 PDS 中 CS 的潜在预测因素。
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