Vertii Anastassiia
Department of Molecular, Cellular and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, United States.
Front Cell Dev Biol. 2021 Dec 14;9:790138. doi: 10.3389/fcell.2021.790138. eCollection 2021.
The exponential development of methods investigating different levels of spatial genome organization leads to the appreciation of the chromatin landscape's contribution to gene regulation and cell fate. Multiple levels of 3D chromatin organization include chromatin loops and topologically associated domains, followed by euchromatin and heterochromatin compartments, chromatin domains associated with nuclear bodies, and culminate with the chromosome territories. 3D chromatin architecture is exposed to multiple factors such as cell division and stress, including but not limited to mechanical, inflammatory, and environmental challenges. How exactly the stress exposure shapes the chromatin landscape is a new and intriguing area of research. In this mini-review, the developments that motivate the exploration of this field are discussed.
研究不同层次空间基因组组织的方法呈指数级发展，这使人们认识到染色质景观对基因调控和细胞命运的贡献。三维染色质组织的多个层次包括染色质环和拓扑相关结构域，其次是常染色质和异染色质区室、与核体相关的染色质结构域，最终是染色体区域。三维染色质结构受到多种因素的影响，如细胞分裂和应激，包括但不限于机械、炎症和环境挑战。应激暴露究竟如何塑造染色质景观是一个新的且引人入胜的研究领域。在这篇小型综述中，将讨论推动该领域探索的进展。
