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具有广义发生率函数的传染病模型的随机分岔分析和随机时滞最优控制。

The stochastic bifurcation analysis and stochastic delayed optimal control for epidemic model with general incidence function.

机构信息

Department of Mathematics, Sun Yat-sen University, Guangzhou 510275, People's Republic of China.

出版信息

Chaos. 2021 Dec;31(12):123101. doi: 10.1063/5.0063050.

DOI:10.1063/5.0063050
PMID:34972335
Abstract

In the history of the world, contagious diseases have been proved to pose serious threats to humanity that needs uttermost research in the field and its prompt implementations. With this motive, an attempt has been made to investigate the spread of such contagion by using a delayed stochastic epidemic model with general incidence rate, time-delay transmission, and the concept of cross immunity. It is proved that the system is mathematically and biologically well-posed by showing that there exist a positive and bounded global solution of the model. Necessary conditions are derived, which guarantees the permanence as well as extinction of the disease. The model is further investigated for the existence of an ergodic stationary distribution and established sufficient conditions. The non-zero periodic solution of the stochastic model is analyzed quantitatively. The analysis of optimality and time delay is used, and a proper strategy was presented for prevention of the disease. A scheme for the numerical simulations is developed and implemented in MATLAB, which reflects the long term behavior of the model. Simulation suggests that the noises play a vital role in controlling the spread of an epidemic following the proposed flow, and the case of disease extinction is directly proportional to the magnitude of the white noises. Since time delay reflects the dynamics of recurring epidemics, therefore, it is believed that this study will provide a robust basis for studying the behavior and mechanism of chronic infections.

摘要

在世界历史上,传染病已被证明对人类构成严重威胁,需要在该领域进行深入研究并迅速加以实施。基于此动机,我们尝试利用具有一般发生率、时滞传播和交叉免疫概念的时滞随机传染病模型来研究此类传染病的传播。通过证明模型存在正的有界全局解,证明了系统在数学和生物学上是恰当的。推导出了必要条件,这些条件保证了疾病的持久性和灭绝性。进一步研究了模型的遍历平稳分布的存在性,并建立了充分条件。对随机模型的非零周期解进行了定量分析。对最优性和时滞进行了分析,并提出了一种预防疾病的适当策略。开发并在 MATLAB 中实施了数值模拟方案,该方案反映了模型的长期行为。模拟表明,噪声在按照建议的流程控制传染病的传播方面起着至关重要的作用,疾病灭绝的情况与白噪声的幅度成正比。由于时滞反映了反复发生的传染病的动态,因此,相信这项研究将为研究慢性感染的行为和机制提供坚实的基础。

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